琥珀酸美托洛尔HPMC骨架片释放影响因素研究.pdfVIP

维普资讯 J生15tom医ed吾匕n学杂志2006；23(3)：587~591 琥珀酸美托洛尔HPMC骨架片释放影响因素研究 黄桂华 王荣梅 王德风 张志文 邓树海 1(山东大学 药学院，济南 250012) 2(山东大学 第二附属 医院，济南 250011) 摘要 以羟丙基 甲基纤维紊 (HPMC)为骨架材料 ，乙基纤维紊 (EC)为阻滞剂，采用湿颗粒压片法制备琥珀酸 美托洛尔亲水凝胶骨架片，考察 HPMC用量、HPMC黏度、EC用量、制备方法、压片压力、释放介质及转速对琥珀 酸美托洛尔 (MS)骨架片体外释药的影响。结果表明，MS骨架片体外释药符合 Higuchi方程 ，药物释放机制是骨架 溶蚀和药物扩散的综合效应 ；HPMC用量与黏度、阻滞剂用量、制备方法、压片压力对释放速率均有显著性影响；释 放介质的pH值及转速对释放速率无显著性影响。 关键词 琥珀酸美托洛尔 羟丙基 甲基纤维紊 骨架片 TheFactorsInfluencingM etoprololSuccinateReleasefrom HydrOxyprOpylM ethylcelluloseM atrix Tablet HuangGuihua W angRongmei WangDefeng ZhangZhiwen DengShuhai 1(InstituteofDrugPreparations，Schoolof Pharmacy．ShandongUniversity，Ji’nan 250012。China) 2(TheSecond AttachedHospital，SandongUniversity，Ji’nan 250011，China) Abstract Thehydroxypropylmethylcel1ulose(HPMC)matrixtabletcontainingmetoprololsuccinate (MS)as flmodeldrugwasobtainedbywetmethodcompressiontablet．TheeffectsoftheamountandviscosityofHPMC， thepreparationmethod，compressingpressure，theamountofethycellulose (EC)，thepH ofdissolutionmedium andthespeedofbasketrotationonthedrugreleasefrom thematrix tabletswereevaluated．Theresultsshowed thatthereleaserateofmetoprololsuccinatefrom HPMC matrixtabletsfollowed Higuchiequation．Therelease mechanism wasin linewiththesyntheticaleffectofdiffusion andcorrosion．Drug releasewasinfluencedbythe amountandviscosityofHPMC，theamountofEC inmatrices，thepreparationmethodandcompressingpressure， etc．Drug release was notinfluenced by thepH ofdissolution medium used，and notby thespeed ofbasket rotation，either． Keywords Metoprololsuccinate(MS) Hydroxypropylmethylcel1ulose(HPMC) Matrixtablets 讨处方、工艺因素对骨架缓释片释药