瘦素与慢性阻塞性肺疾病患者营养不良和呼吸肌疲劳的关系探讨_胡智慧.pdfVIP

( ) 2009 9 30 9 389 ¹ ¹ * 胡智慧 李永春 : 目前大量研究表明血清瘦素在慢性阻塞性肺疾病( COPD) 患者营养不 病理生理机制中发挥重要作用, COPD 患者 多伴有呼吸肌疲劳, 严重呼吸肌疲劳最终导致呼吸衰竭而危及生命, 本文旨在综述瘦素营养不 及呼吸肌疲劳之间的联 系, 以期从新的角度和细胞因子水平来探讨呼吸肌疲劳, 为临床治疗呼吸肌疲劳, 最终治疗呼吸衰竭提供新的方向 : 瘦素, 营养不 , 呼吸肌疲劳 : R562. 25 : A : 1002- 0772( 2009) 9- 0046- 03 The Relationship between Leptin and Malnutrition in Patients with COPD and Respiratory Muscle Fatigue H UZhi-hui, LI Yong-chun. Resp iratory Medicine of the First Af f iliated H osp ital of L iaoning College of Medicine ep artment, Jinzhou 12100 1, China Abstract:T he curr ent tudy how that a lar ge number of erum L eptin in the pathophy iology of COPD patient w ith mal- nutr itio n play an important role in the mechani m of COP D pat ient w ith re piratory mu cle fatigue, ev ere re piratory mu cle fatigue and ev entually lead to life- thr eatening re piratory failur e. T hi article provide a ummary of L eptin, mal- nutr itio n and t heir co nnection w ith r e piratory mu cle fatigue, and it ex plore a new point of view in cy tokine level that clinical tr eatment of r e pir atory mu cle fatigue and ultimately the tr eatment of r e pir atory failur e t o pr ov ide a new re earch direction. Key Words:L eptin, malnutr itio n, re piratory mu cle fat igue 1 OBR , 1. 1 ) ) ) , 15 1994 , OB- R, Zhang ( ob/ ob) O B- R 6 ( ob ) , O B- R, , DNA ob , 166/ 167 , ob/ ob , , db/ db , ob/ ob [ 1] 1995 , I e ob , db/ db ob 7 3 1 3 , , [ 1] ( 7q3