进展型脑梗死患者止凝血相关因子变化的研究.pdfVIP

2008 19 3 Me ical Laboratory Science an Clinics, 2008, Vol19, No. 3 ! 91 ! 1 2 杨玉然 高 阳 1( 济南市传染病医院, 山东济南 250021) 2( 山东省交通医院, 山东济南 250021) 目的 通过对比研究进展型脑梗死与完全型脑梗死患者的 血抗 和纤溶系统功能指标的变化, 探讨进展型 脑能死的发病机制, 为其临床早期诊断和治疗提供依据方法 检测了209例进展型脑梗死患者与209 例完全型脑梗死患者 的血浆 血抗 及纤溶系统指标, 并进行比较结果 进展型脑梗死患者血浆 血酶原时间(PT) 血酶时间(TT) 部分 血活酶时间(APTT) 显著低于完全型脑梗死患者, 而纤维蛋白原( Fg) 血小板 集率( PAgT) 和血管性血友病因子(vWF) 水平显 著高于完全型脑梗死患者进展型脑梗死患者抗 血酶活性(AT) 抗 血酶抗原含量和组织型纤溶酶原激活物(t- PA) 水平 显著低于完全型脑梗死患者结论 进展型脑梗死患者存在着较高的 血活性和较低的抗 和纤溶活性, 临床上可以用 血抗 和纤溶系统功能指标的水平联合判断进展型脑梗死的预后,指导临床抗 溶栓治疗 进展型脑梗死; 血; 抗 ; 纤溶 Investigation of changes hemostatic and coagulative factors in progressive cerebral infarction Yang Yuran, Gao Yang ( Jinan infectious isease hosptial, Shang ong traffic hosptial, Jinan, 250021, China. ) Abstract Objective In or er to early iagnose progressive cerebral infarcion an have more time in thrombolytic treatment.The unique clinical classification an laboratory test of cerebral infarcion progressive were iscusse . Methods The exploratory research were one in 209 casesprogressive cerebral infarcion. Prothrombin time ( PT) , activate partial thromboplastion time( APTT) , thrombin time (TT) , fibnnogen ( Fg) , von Willebran factor(vWF) , platelet aggregation test(PagT) , anti- thrombin activity ( AT) , anti- thrombin antigen(AT) , tissue plas minogen activator activity (t- PA) in the patients were assnye . Results PT, APTT an TT in the patients with progressive cerebral infarcion were significant shorter than that of patientswith complete cerebral infarcion. But the concentration of Fg an vWF in the patientswith progres sive cerebral infarcion were signicant higher than that of patientswith complete cerebral infarcion. PagT in the paients with progressive cerebral infarcion were signicant higher than that of patientswith comp