脑超声造影中超声造影剂剂量对血脑屏障通透性的影响_刘平.pdfVIP

2005 2111 21 112005 Chinese J Ultrasound Med Vol No 801 刘平　高云华　谭开彬　刘政　黄嘉　朱小虎 60 , , , SD 50 Ll/ kg , , , Effects of Different Dosage of Ultrasound Contrast Agents on Blood Brain Barrier in Cerebral Ultrasound Imaging Liu Ping Gao Yunhua Tan Kaibin et al, , , Department U ltrasound, inqiao Hospital of the Third M ilitary Medical University, Chongqing400037China Abstract: ObjectiveTo investigate the effect of the different dosage of ultrasound contrast agents on the ( ) . permeability of the blood brain barrier BBB in the cerebral ultrasound imaging Methods Sixty rats were included in the experiment and a high mechanical index (MI) was applied, different dosage of Zhifuxian were used and the change of the blood-brain barrier was investigated.ResultsWhen the dose of the ultrasound contrast agent was 50 Ll kg there was significant change of the BBB and along with the increase of the contrast agents dosage the severe/ , , . , permeability of the BBB occurred Conclusions With the same intensive ultrasound the number of the microbubbles of the contrast agents was the main factor which results in the different bio-effect . Key ords: Ultrasound contrast agent Blood brain barrier Evans blue, , . , ? [ 1] , ? , , [2] , , , [3,4] , [5] , , , , : SD 60 , , [4, 6] , 200350 g, 245 g, , , 3%30 m