诱导HO_1基因表达的信号通路.pdfVIP

26 3 V ol. 26 N o. 3 2006 6 In ternat ional Journal of P ath ology and C lin icalM ed icine Jun. 2006 HO-1 杨晓瑜 综述 黄维义 魏宗德 审校 (泸州医学院附属医院心内科 四川泸州 646000) [ ] 血红素氧合酶( H O ) 的诱导型 H O- 1与其催化血红素降解生成的 物胆红素和 CO 一道 组成了机 体重要的内源性保护系统 广泛参与抗炎与多种急慢性氧化应激损伤多种理化因素通过不同的细胞内信号转导 通路诱导 H O-1的表达 这些信号通路涉及丝裂原活化蛋白激酶( MA PK s) 蛋白激酶 C( PKC ) cAM P依赖的蛋白激 酶A ( PKA ) cGM P依赖蛋白激酶 G ( PKG ) 酪氨酸蛋白激酶 ( TPK ) 蛋白磷酸酶 ( PP s) 磷脂酰肌醇 ( -3 ) 激酶 ( P I3K ) / Ak t [ ] H O- 1; 信号通路; 谷胱甘肽 [ ] R 55 [ ] A [] 1673-25 88( 200 6) 0 3-0238-05 Signal transduction pathway s of h em e oxygenase-1 gene exp ression YANG X iao-yu HUANG W ei-y i WE I Zong-de (Department of CardiovascularD isease, Aff iliatedH osp ital of Lu Zhou M edicalCollege, Luzhou 646000, China) [ Ab stract] H em e oxygenase- 1( HO- 1) the indu cible iso form o f hem e oxygenase and b iliverd in as w ell as carbon m onox ide the product o fHO- 1 degrad ing hem e con stitute the m ajor endogenou s pro- tect ive system in organism wh ich w idely participates in anti- in flamm atory and mu lt iple acute and chronic ox idative stress injury. M any physical and chem ica l factors indu ce HO-1 expression by variou s intracellu- lar signal tran sdu ction pathw ays such as m itogen-activated pro tein k inases( MA PK s) prote in kinase C ( PKC ) cAM P-dep endentprote in k inase A ( PKA ) cGM P-dependent prote in kinase G ( PKG ) tyrosine prote in k inase( TPK ) pro te in phosph atase( PPs) and phosph atidy linosito l 3-k inase( P I3K ). There is a significance in preventing and trea ting