DNA+分子热变性中随机动力学.pdfVIP

DNA 分子热变性中随机动力学 DNA 分子热变性中随机动力学 邓茂林 ，朱位秋 （浙江大学航空航天学院应用力学所，浙江，杭州，310027） 摘 要：尽管 DNA 分子的研究主要是在生物学领域内进行的，但是目前也有力学理论用于对它的动力学 行为研究。从力学的角度来看，DNA 是一个复杂的多自由度非线性振动系统，一些力学模型可用来理解或 研究 DNA 分子的生物学行为。在本文中，Hamilton 系统理论框架内的非线性随机动力学理论与方法被用 来研究 DNA 分子的热变性。首先，介绍了一种基于 DNA 分子二级结构的 Peyrard-Bishop-Dauxois 力学模 型。通过观察 DNA 模型的动力学行为来理解 DNA 的热变性；其次，用所提出的理论和方法得到 DNA 模 型动力学行为的统计量，包括平均能量的分布和首次穿越时间。最后，通过与来自 Monte Carlo 数字模拟实 验得到的结果相比较，证实了所得理论结果的正确性。由于能量在 DNA 热变性中起着重要的作用，因此， 本文分析能量的理论方法将有助于理解和预测 DNA 分子的动力学行为。 关键词：DNA ；PBD 模型；热变性；随机平均法；首次穿越时间 Stochastic dynamics of DNA thermal denaturation DENG Mao-Line, ZHU Wei-Qiu (School of Aeronautics and Astronautics, Zhejiang University, Hangzhou 310027, China) Abstract ：Although the behavior of DNA is an essential object of study for biologists, its dynamics were also investigated by using the mechanical theory. From the physical point of view, DNA is usually regarded as a complex nonlinear vibrational system with many thousands degrees of freedom. Many corresponding physical models are built for using to investigate or understand the biological behavior of DNA. In this paper, the DNA thermal denaturation is theoretically analyzed by using the nonlinear stochastic dynamics theory for quasi Hamiltonian systems. Firstly, a kind of second hierarchy model for DNA structure, i.e., the model of Peyrard-Bishop-Dauxois, is introduced. And then the dynamical behavior of the DNA model is briefly observed for understanding the thermal denaturation of DNA. Secondly, the proposed theoretical method is used to obtain the statistical properties for the behavior of the DNA model including stationary distribution of average energy and the mean first passage time. Finally, the validity of some obt