我院3673株临床分离菌药敏分析.pdfVIP

我院3673 株临床分离菌与药敏分析 1 李炜清 黄雅萍 （上海市第二人民医院药剂科，院感办， 上海 200011 ） [摘要] 目的 了解我院抗菌药物应用与病原菌耐药现状，探讨抗菌药物用量与细菌耐药性变迁之间的 关系，指导临床合理用药。方法 收集、统计对比分析2007 年～2008 年住院部常用抗菌药物应用频度 与病原菌的耐药率。结果 2 年来，11 种抗菌药物应用频度(DDDs)增长迅速，增长率大于20% 。病原 菌监测结果显示标本阳性率55.88 %，其中革兰氏阴性杆菌56.39%，革兰氏阳性球菌13.58%，真菌28.65 % ，主要分布于呼吸道、泌尿道、皮肤与组织。分离率排序前5 位的病原菌分别是大肠埃希菌、肺炎克 雷伯杆菌、金黄色葡萄球菌、鲍曼不动杆菌和铜绿假单胞菌，多药耐药菌株分离率及耐药率以不同程度 逐年上升。结论 需要加强临床抗菌药物应用管理与细菌耐药谱的监测，延缓及防止细菌耐药菌株的产 生与传播。 [关键词] 抗菌药物；应用频度；耐药率；合理用药liweiqing2@126.com Drug-sensitivity analysis of the 3673 clinical isolated bacillus strains in our hospital 1 LI Wei-qing ， HUANG Ya-ping （Dept. of Pharmacy of Shanghai Second Peoples Hospital，Shanghai 200011） [ABSTRACT] AIM To investigate the use of antibacterials and microbial resistance and trends, to explore the relationship between antibacterial consumption and resistance rate of pathogenic in order to guide rational drug usage in the clinic. METHODS The DDDs of antibacterial drug and drug resistance rates from 2007 to 2008 were collected and analyzed statistically in the inpatients.RESULTS The DDDs of 11 antibacterials showed a great increase in the 2 years. The monitored results of bacterial showed that the detetion-rate of pathogenic bacteria was 55.88%，of which 56.39% were Gram-negative bacilli，13.58% were Gram-positive cocci，and 28.65% were fungi，which were mostly found in respiratory tract，genitourinary tract， skin and organization.Leading the first 5 places in the list of the isolated clinical pathogenic bacteria were Escherichia coli，Klebsiella pneumoniae，Staphylococcus aureus，Acinetobacter baumanii and Pseudomonastdrug.The isolated-rate and resistance rate of pathogens were increasing year by year in various degrees. CONCLUSIONS It is necessary to strengthen the administration of the clinical antibacterial drug usage and the monitoring of the clinical resistance,there by delay the occurrence