唾液酸的研究进展_刘志东.pdfVIP

1, 2 2 2, * 2 2 1 2 , , , , , , ( 11上海交通大学生命科学技术学院, 上海 200090; 21光明乳业技术中心, 上海 200436) : 唾液酸是一系列的 9-碳酸性单糖, 是高 动物和某些微生物具有的重要分子唾液酸在原核和真核生物的 生理反应和特征方面具有重要的作用唾液酸与复杂的糖结合并占据了重要的位置, 特别是在细胞膜上它们保护 了生物大分子和细胞免受酶和免疫的攻击由于其结构的高度多样性, 其生物合成机制也是复杂的本文综述了近 年来唾液酸的制备分离纯化检测方法生物活性和应用现状的研究进展, 并对其未来的发展方向进行了展望 : 唾液酸, 制备, 分离纯化, 检测, 生物活性 Resea rch advances in s ia lic ac ids 1, 2 2 2, * 2 2 1 2 L IU Zh i- don g , W ANG Y in- yu , GUO Ben- h eng , L IU Zhen-m in , SU M i- ya , L i Yun- fei, GAO H on g- yan ( 11School of L ife Sciences and B iotechnology, Shanghai iaotong University, Shanghai 200090, China; 21T echn ical Center, Bright Dairy Co1L td1, Shanghai 200436, Ch ina) Abstrac:t S ia lic ac id s are a series o f 9- ca rbon ac id ic m onosaccha rides w hich be long to the m os t mi p ortan t m o lecu les of highe r anmi a ls and a ls o occur in som e m ic roo rgan ism s 1S ia lic acid s p lay an mi p o rtant ro le in the p hys io log ica l reac tions and cha rac teris tics o f p roka ryo tes and euka ryo tes 1S ia lic ac id s a re b ound to com p lex ca rbohyd ra tes and occup y p rom inen t p os itoi ns, espec ia lyl in ce ll m em b ranes 1They sh ie ld m ac rom o lecu les and ce lls from enzym a tic and mi m uno log ica l a ttacks 1Due to the ir h gi h s truc tu ra l d vi e rs ity, the m echanism s for the ir b ios yn thes is a re com p lex1The p rod uction, iso la tion and pu rification, de te rm ni a tion m ethod s and b oi log ica lac tiv ities w e re review ed, the ap p lications o f s ia lic ac id s w e re in troduced and the fu tu re d irec toi ns o f s ia lic ac id