EffectofSairei-toandits：对柴汤及其影响.pdfVIP

in vivo 22: 57 1-576 (2008) Effect of Sairei-to and its Ingredients on Prostaglandin E2 Prod ction by Mo se Macrophage-like Cells 1,4 1 2 ,4 4 TADAYOSHI KANEKO , HIROSHI E CHIBA , NORIO HORIE , TAKAO KATO , 3 4 3 KEN HASHIMOTO , KAORU KUSAMA and HIROSHI SAKA AMI 1Dep artment of Oral and ax illof acial Surgery, Tokyo edical University, Shinj yuku-ku, Tokyo; 2Dep artment of Oral and ax illof acial Surgery, Saitama edical University, Kawagoe, Saitama; Divisions of 3Pharmacology and 4Pathology, Dep artment of Diagnostic and Therap eutic Sciences, eikai University School of Dentistry, Sakado, Saitama, Jap an Abstract. Sairei-to and its twelve ingredients were the production of inflammatory mediators such as prostaglandin investigated f or their activity to stimulate p rostaglandin E E (P E ) , or nitric oxide (NO) by down-regulating COX-2 or 2 2 2 (PGE ) p roduction by unstimulated and lip op olysaccharide inducible NO synthase (iNOS) expression (3) . 2 (LPS) -stimulated mouse macrop hage-like RAW 264 .7 cells . Sairei-to, one of the Kampo medicines, is composed of 12 LPS signif icantly stimulated the p roduction and extracellular major ingredients (Bup leuri radix, Pinelliae tuber, Scutellariae secretion of PGE2 by RAW 264 .7 cells. Sairei-to concentratio