中药复方透皮贴剂的皮肤用药安全性研究.pdfVIP

畜牧与饲料科学 Animal Husbandry and Feed Science 2010 ，31 （3 ）:52-54 中药复方透皮贴剂的皮肤用药安全性研究 周 凡，冯士彬，孟庆娟，韩春杨，王希春，吴金节 （安徽农业大学动物科技学院，安徽 合肥 230036 ） 摘要：通过对健康家兔皮肤急性毒性试验、皮肤刺激性试验及健康豚鼠皮肤过敏性试验，观察中药复方透皮贴剂经皮肤 用药的急性毒性、刺激性和过敏性。 结果显示，中药复方透皮贴剂对家兔完整皮肤和破损皮肤均无急性毒性和刺激性， 对豚鼠完整皮肤无致敏作用。 试验表明，中药复方透皮贴剂经皮肤给药安全。 关键词：中药；透皮贴剂；急性毒性；皮肤刺激性；皮肤过敏性 中图分类号： 文献标识码： 文章顺序编号： （ ） R283 A 1672-5190 2010 03-0052-03 Enepidermic Reliability of Compound Traditional Chinese Medicine Transdermal Patch ZHOU Fan, FENG Shi-bin, MENG Qing-juan, HAN Chun-yang, WANG Xi-chun, WU Jin-jie （College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China ） ： Abstract The aim of this research was to survey acute toxicity, irritation and hypersensitivity of compound traditional Chinese medicine transdermal patch on animal skin through skin acute toxicity and skin irritation test in healthy rabbits and dermal sensitivity test in healthy guinea pigs. The result showed that the compound traditional Chinese medicine transdermal patch had no acute toxicity and no irritation on integrated and worn skin of rabbits, and it had no hypersensitivity on integrated skin of guinea pigs. The experiment indicated that it is safe to administrate the compound traditional Chinese medicine transdermal patch via skin. ： Key words traditional Chinese medicine; transdermal patch; acute toxicity; skin irritation; skin hypersensitivity 中药复方透皮贴剂是按照中兽医辨证施治的理论和奶 pH 值至6.5～7.5 ，即得中药复方提取浓缩液。 牛乳房炎的病理特征， 研制出的一种通过经皮肤给药治疗 中药复方透皮贴剂的制备： 精密称取处方量的聚乙烯 奶牛乳房炎的纯中药外用制剂，由七叶一枝花、半枝莲、黄