基因表达谱聚类_分类技术研究和展望_李杰.pdfVIP

21 4 Vol.21 No.4 2005 7 Chinese Journal of Biotechnology July 2005 P Research on Gene Expression Data Based on ClusteringP classification Technology 1 1* 1 1, 2* 李 杰, 唐降龙 , 王亚东 , 李 霞 1 1* 1, 2* LI Jie , ANG Xiang-Long ,WANG Ya-Dong and LI Xia 11 , 150001 21 , 150086 11School of Computer Science and Technology ,Harbin Institute of Technology, Harbin 150001, China 21Dep artment of Bioinf ormatics, HarbinMedical University, Harbin, 150086, China 随着人类及多种模式生物全基因组测序基本完成, 人类基因组计划的研究进入后基因组时代. 后基因组时代研究的 焦 已经从测序转向功能研究聚类P分类技术作为分析基因表达谱和识别基因功能的重要工具之 一, 近年来获得很大的发 展对目前基因表达谱聚类P分类技术及它们的发展, 进行了综述性的研究,分析了它们的优缺 , 结合我们的研究, 提出了解 决问题的思路和方法, 为基因表达谱的进一步研究提供了新的途径 基因表达谱, 分类, 聚类, 基因调控网络, 逆向工程 Q78 A 1000-3061( 2005) 04-0667-07 Abstract As thework of sequencing the genome of the human and many model organisms has been partially or fully finished, the 0postgenomic era0 has begun. Scientists are turning their focus toward identifying gene function from sequencing. Clustering technology, as one of the important tools of analyzing gene expression data and identifying gene function, has been usedwidely. In this paper we discuss main clustering technology about gene expression data at present, analyze their advantages and disadvantages, present the methods to solve the problems and give new approaches to study gene expression data. Key words gene expression data, classification, clustering,gene regulatory network, reverse engineering , , , ,