吲哚-6-酰腙类化合物的微波合成及其抗菌活性研究.pdfVIP

2009 年第 29 卷 有 机 化 学 Vol. 29, 2009 第 6 期, 993～997 Chinese Journal of Organic Chemistry No. 6, 993～997 ·研究简报· 吲哚-6-酰腙类化合物的微波合成及其抗菌活性研究 叶 英 赵志刚* 刘兴利 李清寒 (西南民族大学化学与环境保护工程学院 成都 610041) 摘要 把酰腙类结构引入吲哚环中, 合成一类新型的吲哚-6-酰腙化合物, 以期为新药筛选提供先导化合物. 在微波辐 1 射条件下, 以较高的产率得到 14 个未见报道的新化合物, 其结构均经 H NMR, IR, MS 及元素分析确证, 并测试了化合 物的抑菌活性. 关键词 吲哚; 酰腙; 抗菌活性; 微波辐射 Microwave-Assisted Synthesis of Indole-6-acylhydrazone and Their Antibacterial Activities Ye, Ying Zhao, Zhigang* Liu, Xingli Li, Qinghan (College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041) Abstract A novel type of indole-6-acylhydrazone compounds have been designed and synthesized by connecting the structure of acylhydrazone to indole ring, with a view of providing lead compounds for the screening of new dugs. Fourteen new compounds have been obtained with high yields under the conditions 1 of microwave irradiation, and the structures of all new compounds were characterized by H NMR, IR, MS techniques and elemental analysis. Their antibacterial activities have been tested against three kinds of bac- teria. The preliminary results show that the compounds possess different inhibitive effects. Keywords indole; acylhydrazone; antibacterial activity; microwave irradiation 吲哚是一类非常重要的杂环医药和有机化工中间 治疗一些疾病和抑菌方面已有广泛的应用.