治疗类风湿性关节炎中药复方白仙风汤剂的药理作用研究.pdfVIP

LISH IZH EN MEDICINE AND MATERIA MED ICA RESEARCH 2008 VOL. 19 NO. 10 2008 19 10 郭丽冰, 王 蕾, 林 爽, 潘贞芸 (, 510006 ) : 研究治疗类风湿性关节炎的中药复方白仙风汤的药理作用 采用小鼠扭体镇痛试验和小鼠耳二甲苯 致炎抗炎试验对白仙风汤不同提取方法的提取物进行药理指标考察, 选择较优的提取方法, 再进行大鼠佐剂关节炎试 验 白仙风汤方法 (水醇分提法) 提取物能显著镇痛和抑制小鼠耳肿胀度, 白仙风汤中高剂量给药组能显著抑 制佐剂关节炎大鼠足肿胀度 白仙风汤具有 一定的抗类风湿性关节炎作用 : 中药复方; 类风湿性关节炎 ; 药理实验; 镇痛抗炎作用 : R285. 5 : A : 2008) The Pharmacological Effect of A Chinese Compound Formula Baixianfeng Decoction Used for Therapy forRA GUO L ibing, WANG Le,i L IN S uang, PAN Z enyun (Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510006) Abstract: bjective To study t e p arm acolog ical effect of a C inese com pound formu la Baixianfeng Decoction used for t erapy r eum atoid art ritis ( RA). Methods D ifferent extraction met ods for Baixianfeng w ere c osen by t e writ ing test and ear sw ell ing test in m ice. Adjuvant A rt ritis of Rats expermi ent w as used on t e better one. Results T e extract of m et od ad signifi cant analgesic effect and cou ld in ibit t e ear sw elling degrees of m ice. T e ig and m idd le dosage of Baixianfeng Decoction could sign ificantly in ib it t e feet swelling degrees of rats. Conclusion Baixianfeng Decoction asd anti- RA effect. Key words:C inese com pound form ula; R eum atoid art ritis ( RA); P arm acological expermi ents; An ti- inflamm ato ry and analgesic effect ( R eum atoid A rt ritis, RA) 1. 4 试剂 95% , (); CMC- N a, ( ); , , ! ∀, 2 , , , 2. 1 供试品的提取与制备 : [ 1, 2] (# ) ( ) : 10 , 1 /, , , , , : , (AA) , ( , 70% , , 10 , 1 /, )(, 10 2, 1 1 /, ) ,