活性炭对甘草酸二铵磷脂复合物注射液含量的影响_孙宇.pdfVIP

第 27 卷 第 12期 Vol. 27 N o. 12 2 0 0 9年 12月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE De . 2 0 0 9 孙 宇, 陈晓瑾, 茹仁萍 (, 310014) : 目的: 考察活性炭对甘草酸二铵磷脂复合物 ( GPC) 射液生产工艺过程的影响, 寻求最佳生产工艺 方法: 通过正交设计考察加炭量活性炭的加入方式加热温度以及加热时间 4 个因素对药物含量的影响, 采用 4 L ( 3 )正交表进行了详细的考察结果: 正交试验结果表明, 活性炭在加热前加入, 加入量为 0. 05% , 加热温度 9 为 80e , 加热时间为 35m in时对药物的吸附量最少结论: 生产过程中应该对上述因素进行控制, 以保证产品的 质量 : 甘草酸二铵磷脂复合物; 射液; 活性炭; 正交设计 : R285 : A : 1673- 77 17( 2009) 12- 2615- 02 E ffects of A ctivated Carbon on Conten t of D iamm on ium G ly cy rrh izinate Phospholip id Com p lex Injection SUN Yu, CHEN X iao-jin, RU Ren-p ing (Th e Six th People. sH osp ital ofH angzhou, H angzhou 310014, Zhejiang, Ch ina) Abstrac:t O bj ect iv e: To study the effe ts of a tivated arbon on ontent of d iammon ium gly yrrhizinate phospholipid 4 om plex inje tion. M ethods: T o arrange the test a ording to the L ( 3 ) orthogonal tab le, w e sele ted four fa tors as dos- 9 age of a tivated arbon, the temperature of the solution, the tmi e of heating, the add ingm ethod of a tivated arbon, ea h ofwh i h took three levels, and the ontent of diamm onium gly yrrh iz inatew as hosen as the index. R esults: The experi- m ent resu lts indi ated that a tivate arbon sign ifi an tly absorbed the d iamm onium gly yrrhizinate in solution. The opti- m um te hn ique w as that the dosage of a tivated arbon was 0. 05% , the temperatu re w as 80e , the tmi e of heating w as 35m in, adding the a tivated arbon before heating. Under this