温脾实肠法组方治疗脾阳不足泄泻的_省略_AMS_LDH及SDH活性的影响_朱吾元.pdfVIP

第 29 卷 第 1期 Vol. 29 No. 1 2 0 1 1年 1月 CHINESE ARCHIVES OF TRADITOI NAL CHINESE MEDCI INE Jan. 2 0 1 1 AMSLDH SDH 1 2 朱吾元, 朱萱萱 ( 1. , 210029; 2. , 210029) : 目的:观察温脾实肠法组方对脾阳不足泄泻模型大鼠血 中酶活性的影响, 探讨温脾实肠颗粒治疗 脾阳不足泄泻的机理方法: 取 SD大鼠 60只, 雌雄各半, 随即分为正常对照组模型对照组附子理中丸组温脾 实肠大剂量组温脾实肠中剂量组温脾实肠小剂量组, 每组 10只除正常对照组外, 其余各组采用苦寒药物加 饮食失节法造成大鼠脾阳虚泄泻模型造模结束后给予相应药物治疗 14天, 末次给药 1h, 眼眶静脉丛取血, 测 定血 中淀粉酶乳酸脱氢酶琥珀酸脱氢酶水平结果: 脾阳不足泄泻模型组 AMS 及LDH 水平明显低于正常 对照组经药物治疗后温脾实肠颗粒能明显提高模型大鼠血 中AMS及 LDH 水平脾阳不足模型大鼠血 中 SDH 水平明显高于正常对照组, 温脾实肠颗粒可降低模型大鼠血 中 SDH 水平结论: 温脾实肠颗粒对脾阳不 足泄泻的治疗作用与调节血 中消化酶水平有关 : 温脾实肠法; 脾阳不足泄泻; AMS; LDH; SDH : R285. 5 : A : 1673 7717( 2011) 01 0141 03 The Expermi entalStudy of enpishcihang FormulaonRatswith Diarrhea the LevelsofAMS, LDH and SDH inSerum 1 2 ZHU W u yuan , ZHU Xuan xuan ( 1. Nanjing U niversity ofT raditionalChineseM edicine, N anjing 210029, Jiangshu, China; 2. Jiangsu ProvinceHospital of TCM, Nanjing 210029, Jiangshu, China) Abstrac:t O bj ect iv e: Observe the effection ofwenp ish ichang formu la on the levels of d igestive enzymes in serum of rats w ith d iarrhea. M ethods: SD ratsw ere taken 60, m ale and fem ale in half, then divided into norm al control group, model control group, fuzilizhong Pill group, h igh dose group, m iddle dose group and low dose group, 10 rats in each group. The d iarrhea m odel of ratsw ere induced by dahuang decoction. The AM S, LDH and SDH in serum w ere deter m ined after the last treatm ent. R esult: wenp ish ichang form ula obviously increased AM S and LDH activity, and also de creased serum SDH activity. Conclusion: W