血管内皮生长因子受体的结构与功能.pdfVIP

·18 · 生物化学与生物物理进展 　　Prog. Biochem. Biophys. 　　　　　1997 ; 24 ( 1) 20 Keller E T , Ershler W B . Effect s of IL6 receptor antisense interact t hrough a heterohaxmer module , oligodeoxynucletics on i n v it ro proliferation of myeloma sequentially t rigger s t he signal t ransduction cells. J Immunol , 1995 , 154 : 409 1～4098 2 1 Klein B , Brailly H. Cytokinebinding proteins : stimulating wit hin t he cell . There exist two signal t ransduc antagonist s. Immunology Today , 1995 , 16 : 2 16～220 tion p at hways : J akSTA Ts p at hway and Ras MA P K cascade p at hway . Any factor t hat can Interleukin 6 Signal Transduction and the block or interfere wit h t he signal t ransduction of Strategies in Treatment f or IL6related Dis IL6 will be a considerable st rategy in t reat ment eases. DUAN J ubao , WAN G J iaxi ( I ns t it ute of for IL6 related diseases. These st rategies B as ic M edical S ciences , A cademy of M il it ary include growt h factor s , monoclonal antibodies , M edical S ciences , B eij i ng 100850 , China) . ant agonist s , antisense gene and so on . The Abstract 　Interleukin 6 is a multiple function st udy on t he p harmaceutical design and selection cytokine , playing an import ant role in modulat t argeting to signal t ransduction of IL6 will p ro ing immune response , hematopoeisis , acute mote t he t reat ment for IL6related diseases. p hase reaction and so on . On t he ot her hand , The twochain receptor system of IL6 and it s overexp ression of IL6 relates to t he p at hogene signal t ransduction have been reviewed , and t he sis and develop ment of many