肥大细胞第研究进展_邓文斌.pdfVIP

2005 16 4 Qilu Journal of Medical Laboratory Sciences, 2005, Vol16, No. 4 # 1 # 邓文斌综述, 李萍审核 ( 四川大学华西医院检验科, 成都610041) = 肥大细胞(MC) 是系统发生学的一种成熟细胞在哺乳动物,MC 分 于除骨软骨和眼球角膜的结缔组织, 并以 相当一致方式围绕血管淋巴管和神经末梢分 MC 是一种成活时间长的多功能分泌细胞, 胞浆内有大量由蛋白多糖基 质肝素组成的高电子密度颗粒它是哺乳动物组织内组胺的主要储藏地本文就MC 的表型测定方法介质等方面的研究 现状作一简要介绍 = 肥大细胞 类胰蛋白酶 类糜蛋白酶 Advancement in researches of mast cell Deng Wenbin,Li Ping Department of Laboratory Tests,West China Hospital,Sichuan University, Chengdu610041,China = Abstract Mast cell is a phylogentically mature cell that appatently occurs in al species with blood circulation. In mammals, mast cells are normal inhabitants of the connecti e tissue except for a ascular tissues shch as mineralized bone, cartilage and the cornea and congregate around blood and lymph micro essels and ner e endings in a remarkably consistent fashion. They are multifunctional long- life secretory cells characterized by their content of numerous large, electron- dense granules that are made up by ora proteoglycan matrix and heparin in particu- lar. The cells are the main repository for histamine in mammalian tissues. In this paper, phenotypes, mediators and methods for measurement of mast cells were briefly re iewed. = ey wordsMast cell Tryptase Chymase (mast cells) CD34c ( CTMC) - kit CD13 , [ 6- 7] [ 1] [ 8] ( commited progenitors) MC , ( ( tryptase) ) ,MC Fc- ERI Fc- CR + ( chymase) ( MCTC or tryptase , chy- Ò/ Ó, + mase ) ; MC ( tryptase) ( B/ MMP- 9) , MC + ( chymase) (MCT or tryp