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Transcription factors that control inner ear development and their potential for.pdf

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Transcription factors that control inner ear development and their potential for.pdf

Hearing Research 297 (2013) 84e90 Contents lists available at SciVerse ScienceDirect Hearing Research journal homepage: www.else /locate/heares Review Transcription factors that control inner ear development and their potential for transdifferentiation and reprogramming Thomas Schimmang* Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientíﬁ cas, C/Sanz y Forés 3, E-47003 Valladolid, Spain a r t i c l e i n f o a b s t r a c t Article history: Transcription factors (TFs) participate during various processes throughout inner ear development such Received 3 September 2012 as induction, morphogenesis and determination of cell fate and differentiation. The analysis of mouse Received in revised form mutants has been essential to deﬁne the requirement of different members of TF families during these 23 October 2012 processes. Next to their roles during normal development TFs have also been tested for their capacity to Accepted 5 November 2012 Available online 14 November 2012 induce differentiation or reprogram cells upon misexpression. Recently the capacity of TFs to trans- differentiate easily accessible cells such as ﬁbroblasts to highly specialized cell types has opened a new pathway for regenerative therapies. In this review the inﬂuence of TFs acting during different phases and pro