Yujun GuoKent State UniversityAugust 13. 2003.ppt

A Binarization Approach for CT-MR RegistrationUsing Normalized Mutual Information Why and What Why medical image registration? Medical image registration has been applied to the diagnosis of breast cancer, cardiac studies, and a variety of neurological disorders including brain tumors. Why mutual information? Maximization of mutual information of voxel intensities has been proved to be one of the most popular registration methods for three-dimensional multimodal medical image registration. What’s the goal of this paper? To develop a registration software. To implement a new approach for multimodality medical image registration. Improve accuracy with no loss of speed. The result could be used in clinical cases. Modalities Involved in Registration Why Registration? Monomodality: A series of same modality images (MR with MR….). Images may be acquired weeks or months apart. Aligning images in order to detect subtle changes in intensity or shape Multimodality: A combination of MR and CT with SPECT or PET. Complementary anatomic and physiological information can be obtained for the precise diagnosis and treatment. Examples:PET and SPECT (low resolution, functional information) need MR or CT to get structure information. In future, medical images (such as PET, SPECT and CT, MR) will be acquired in a single machine. Registration Methods Landmark-based: Based on identification of corresponding point landmarks or fiducial marks in two images. Accurate, but inconvenient, and cannot applied retrospectively. Labor-intensive and their accuracy depends on the accurate indication of corresponding landmarks in all modalities. Surface-based: Corresponding surfaces are delineated and a transformation computed that minimizes some measure of distance between the two surfaces. Segmentation needed, and surfaces are not easily identified in functional modalities(PET). Voxel-based