DNA免疫吸附治疗狼疮性肾炎的近期疗效观察.pdfVIP

DNA免疫吸附治疗狼疮性肾炎的近期疗效观察 江德文 许艳芳 郭淑霞 崔炯 李桂芬 潘阳彬 付槟槟 万建新 【摘要】目的 观察DNA免疫吸附对系统红斑狼疮性肾炎患者的临床疗效。方法 选择26 例活动性系统性狼疮性肾炎患者，采用DNA免疫吸附柱法进行52例次免疫吸附治疗并观察其 临床变化、抗核抗体、抗双链DNA抗体及免疫球蛋白水平等影响程度。结果 经吸附治疗后 患者临床症状明显改善，尿蛋白减轻，抗核抗体滴度治疗前[(3.9±0.6)CO/L]、后[(1.0士 0.3)CO/L]比较差异有统计学意义(P0.01)、抗双链DNA抗体治疗前[(797±103)IU/L]、后 [(94士29)IU/L]比较差异也有统计学意义(P0.01)，而对C 、C 及肝肾功能、电解质等则无 3 4 明显影响。结论 DNA免疫吸附疗法是治疗狼疮性肾炎一种疗效好、无明显不良反应的新方 法，尤其适用于重症系统性红斑狼疮。 【关键词】系统性红斑狼疮；免疫吸附 Short-term efficacy of DNA immunoadsorption in the treatment of lupus nephritis JIANG De-wen, XÜ Yan-fang, GUO Su -xia, CUI Jiong, LI Gui-fen, PANG Yang -bin, FU Bin-bin, WAN Jian-xin. Department of Nephrology, the First Affiliated Hospital of Fujian Medica l University, Fuzhou 350005, China Corresponding author: JIANG De-wen, Email: fjjdw@163.com [Abstract] Objective To observe the DNA immunoadsorbent hemoperfusion on patients with lupus nephitis clinical curative effect. Methods 26 patients with active systemic lupus nephritis patients, using DNA immunoadsorbent blood perfusion device for 52 time of blood perfusion, observation of clinical changes, ANA, ds-DNA and immunoglobulin influence degree. Results the clinical symptoms were significantly improved after adsorption, urinary protein loss, ANA [(3.9 0.6)CO/L vs (1.0 0.3)CO/L, P0.01) ], ds-DNA [(797 103)IU/L vs (94 29)IU/L, ± ± ± 士 P0.01)] levels significantly decreased and had no obviously effect on C3, C4 and liver as well as kidney function, electrolyte. Conclusion DNA immunoadsorbent blood perfusion device purifying therapy is the treatment of lupus nephritis with a strong specificity, good curative effect, no toxic side effect of the new method. The method is especially effective in treatment of severe