动脉粥样硬化性脑梗死患者MMP2、3、9动态变化及和颈部斑块关系研究.pdfVIP

567 doi:10.3969/j.issn.1009-881X.2010.04.019 动脉粥样硬化性脑梗死患者MMP-2 3 9动态变化 及与颈部斑块关系研究 摘要：目的 MMP239方法 ELISA 8224h340 MMP-239 3结果 24h3d MMP-239(P 0.01)MMP-924h MMP-2MMP-3 MMP-9(P 0.01)结论 MMP-239MMP-239 MMP-9MMP-239 关键词：MMP-239 中图法分类号：R743 文献标识码：A 文章编号：1009-881X(2010)04-0567-04 Dynamic Changes of Serum Matrix Metallproteinase-2,3,9 Concerntration in Patients with Atherosclerotic Cerebral Infarction and Carotid Atheroselerosis LIU Xiao-jie,HUANG Jin-zhong,CHEN Ying-zhu,XU Yao,YUAN Chen-lin (Department of Neurology,Northern Jiangsu people’s Hospital Affi liated to Yangzhou University, Yangzhou,225001 ) Abstract Objective To investigate the association of matrix metallproteinase-2,3,9 concentration to atherosclerotic cerebral infarction.Method The study enrolled 82 atherosclerotic cerebral infarction patients (collected 24 hours and 3 days after the onset)and 40 healthy controls.Serum concentration of MMPs was measured by enzyme linked immunoabsorbent assay(ELISA).The atherosclerotic plaques in the carotid arteries were assessed by Color Doppler Ultrasonography.Patient group was divided into three subgroups according to the characteristic of atherosclerosis:unstable plaque group,stable plaque and no plaque group.Result The serum level of MMP-2,3,9 in the patients was signifi cantly higher either in 24 hours or 3 days after the onset than the healthy controls;Compared with the healthy controls,there was signifi cant difference in them.The serum levels of MMP- 2,3,9 in 24 days after the onset in unstable plaque group was signifi cantly higher than stable plaque group and no plaque group. Conclusion There may be