肠道菌群失调和生物钟紊乱的相关性_黄文雅.pdfVIP

·950 · 中国病理生理杂志 Chinese Journal of Pathophysiology 2015 ，31 (5):950-955 ［ ］ 1000-47 18 (2015)05-0950-06 文章编号 · · 综 述 肠道菌群失调与生物钟紊乱的相关性* △ ， ， 黄文雅 陆付耳 董 慧 ( ， 430030) 华中科技大学同济医学院附属同济医院中西医结合研究所 湖北武汉 Ｒelationship between intestinal dysbacteriosis and circadian clock disturbance HUANG Wen-ya ，LU Fu-er ，DONG Hui (Institute of Integrated Traditional Chinese ＆ Western Medicine ，Tongj i Hosp ital ，Tongj i Medical College ， Huazhong University of Science ＆ Technology ，Wuhan 430030 ，China． E-mail :tj hdonghui@ 163． com) ［ABSTＲACT］ The human gut harbours a certain quantity and variety of microbes called intestinal flora ，which is in a state of balance under normal circumstances ，and dysbacteriosis occurs when the balance of the intestinal flora is dis- turbed by the host and the changes of the external environment． Circadian clock is the biological regulation system to adapt to natural circadian rhythm ，including central clock and peripheral clock． Circadian clock disturbance ，particularly rotating shift-workers with irregular light-night schedules ，is associated with an increased risk of immune-related diseases． The de- velopment of these diseases is closely related to intestinal dysbacteriosis． Therefore ，the correlation between intestinal dys- bacteriosis and circadian clock disturbance has attracted much attention． This review aims to explore the pathophysiological basis of the development in some immu