中国传统抗衰老药物黄精的研究进展.docVIP

中国传统抗衰老药物黄精的研究进展 李春生1 侯荣先2 （1.香港东华三院东华东院中医中心工作、中国中医科学院西苑医院主任医师 2.北京：中国中医科学院西苑医院图书馆副研究馆员。） 【摘要】目的：考察抗衰老中药黄精近10年的化学、药理和临床的研究现状。方法：收集1998—2007年间国内外发表的有关黄精及其提取物研究的论文和报道，加以综述。结果：黄精中新发现成分为木质素、特有蛋白质及5种多糖。对其延缓衰老、免疫增强、抗动脉硬化、调节血糖、提高生命活力、抗病毒的研究有所深化，发现本品有较好的抗皮肤衰老、改善记忆、保护脑细胞、抗干眼病、抗结核作用。结论：黄精是一种保健和治疗功效兼备的传统延缓衰老中药。 【关键词】黄精 化学 药理学 衰老/药物作用 综述 The Progress of the Study of Traditional anti-aging Chinese drug Polygonatum sibiricum Delar.ex Redonte 　　 【ABSTRACT】 Objective To investigate the progress of the chemical, pharmacodynamics and clinical study of the anti-aging drug Polygonatum sibiricum Delar.ex Redonte in the recent ten years. Methods Collect and summarize the journals and reports related to the study of Polygonatum sibiricum Delar.ex Redonte and it掇 extracts in Mainland China and foreign countries from 1998 to 2007. Results The new components found in Polygonatum sibiricum Delar.ex Redonte include lignin, special proteins and five kinds of polysaccharides. There are more in-depth researches on the functions of postpone the aging process, to enhance immunity, prevent arteriosclerosis, to regulate blood sugar level, to raise the vitality, and also anti-virus about Polygonatum sibiricum Delar.ex Redonte, It is found that Polygonatum sibiricum Delar.ex Redonte is good for anti-aging of skin, improve the faculty of memory, protect brain cell, anti-xerophthalmia and anti-tuberculosis. Conclusion Polygonatum sibiricum Delar.ex Redonte is a traditional anti-aging Chinese drug which has both health care and treatment function. 【KEY WORDS】 Polygonatum sibiricum Delar.ex Redonte; Chemistry; Pharmacology; Decrepit/Drug effects ; Summary 黄精（Polygonatum sibiricum Delar.ex Redonte）是百合科植物黄精、多花黄精和滇黄精的根茎，属于补益类传统延缓衰老药物。本品味甘性平无毒，归肺脾肾三经，功能滋阴润肺、补脾益气、滋肾填精，长于治疗劳嗽、消渴、少食口干、阳痿遗精、耳聋目暗、须发早白、体虚羸瘦，风癞癣疾等病证。《名医别录》谓其「主补中益气，除风湿，安五脏，久服轻身延年」。新中国成立以来，对黄精做了大量研究，发现本品含有多种甾体皂、黄精多糖、洋地黄糖以及少量葱类化合物等。药理研究证实，本品具有延长家蚕生存期、对抗自由基损伤、增强免疫功能，调节第二信使环磷酸腺（cAMP）水平、增强心肌收缩力、增强冠状动脉血流量、降血糖、降血脂、抗菌、抗病毒、抗幅射、抗突变、抗疲劳等作用。是一种有很好开发前景