信号通路拮抗剂和骨质疏松万雷,黄宏兴,罗明,等.pdfVIP

第 1 6 卷 第 1 2 期 辽宁中医药大学学报 Vol. 16 No. 12 2014 年 12 月 JOURNAL OF LIAONING UNIVERSITY OF TCM Dec .，2014 DOI：10.13194/j.issn.1673-842x.2014.12.028 Wnt/β-catenin 信号通路拮抗剂与骨质疏松 万雷，黄宏兴，罗明，赖圆圆，曾国勇 （广州中医药大学附属骨伤科医院，广东 广州 510240 ） 摘  要：Wnt/β-catenin信号通路是重要的细胞信号转导途径，在细胞的增殖、分化中发挥重要作用。目前 的研究表明Wnt/β-catenin信号通路在骨代谢中发挥重要作用，该通路的异常与骨质疏松的发生有关。Wnt/ β-catenin拮抗剂可以抑制Wnt/β-catenin信号通路，导致通路表达异常，进一步研究Wnt/β-catenin信号通路拮 抗剂，设计出阻断该通路拮抗剂的物质，可为骨质疏松的治疗提供一种新的途径。 关键词：Wnt/β-catenin信号通路；拮抗剂；骨质疏松 ( ) 中图分类号：R681 文献标志码：A 文章编号：1673-842X 2014 12- 0073- 03 Antagonists of Wnt/β-catenin Signaling Pathway and Osteoporosis WAN Lei，HUANG Hongxing，LUO Ming，LAI Yuanyuan，ZENG Guoyong （Affiliated Orthopedics and Trauma Hospital，Guangzhou University of Chinese Medicine，Guangzhou 510240，Guangdong，China） Abstract：Wnt/β-catenin signaling pathway is an important cellular signal transduction pathway and plays an important role in cell proliferation and differentiation. Current researchs indicate that Wnt/ β-catenin signaling pathway is significant in bone metabolism and its abnormalities relate to the occurrence of osteoporosis. Wnt/β-catenin signaling pathway antagonists can inhibit the Wnt/β-catenin signaling pathway and cause the pathway abnormal expression. Further studys of the Wnt/β-catenin signaling pathway antagonists and designing the materials to block the pathway antagonists can provide a new kind of osteoporosis treatment approach. Key words：wnt/β-catenin signaling pathway；antagonist；osteoporosis Wnt/β-catenin 信号通路是一条保守而重要