唑来膦酸治疗氯膦酸二钠耐药的癌性骨转移疼痛疗效观察.pdfVIP

唑来膦酸治疗氯膦酸二钠耐药的癌性骨转移疼痛疗效观察 王谊1★，张智慧1，乐晓燕2，魏素萍1(1．四川省肿瘤医院内科，成都市610041；2．成都温江区人民医院内科， 成都市 611130) 中图分类号 R979．1；R969．4文献标识码 A 文章编号 100卜0408(2008)23—1814一02 摘要 目的：观察唑来膦酸治疗氯膦酸二钠耐药的晚期骨转移疼痛患者的近期疗效和安全性。方法：37例患者既往都用过氯膦 酸二钠治疗≥2周期，以后骨痛再发或加重，给予唑来膦酸注射液4mg加入生理盐水100mL中稀释后静脉滴注，给药时间大于 15 率67．6％(25／37)。主要不良反应为低熟、食欲下降等，无需特殊处理。结论：唑来膦酸能有效缓解对氯膦酸二钠耐药的癌性骨转移 疼痛，防止骨相关事件发生，改善患者生活质量。 关键词唑来膦酸；骨转移性肿瘤；骨痛；氯膦酸二钠 Metastatic CIinicalObservationonZoledronicAcidintheTreatmentofDisodiumClodr蚰ate—resistant TumorOfBone WANG Internal Cancer Yi，ZHANGZhi^ui，WEI Medicine，Sichuan Su—ping(Dept．of 610041。China) YUE Internal District 611130， Xiao—yan(Dept．ofMedicine，ChengduWenjiangPeople’sHospital，Chengdu China) ABSTRACT theshort—termand ofzoledronicacidinthetreatmentofdisodi咖 oBJECTIVE：Tostudy efficacysafety whohadbeentreated clodronate—resistantmetastatictumorsofbone．METHODS：37patientswithmetastatictumorofbone 4 acidi dilutedin100mL saline withdisodiumclodronatefor≥2 weretreatedwith zoledronicnjection physiologic cycles mg than15 3～4weeksforatleast2 total d shouldbefinishedinnoless min)once (intravenousrip per effectiveratein was totaleffectiveratein was67．6％(25／ 64．9％(24／37)．The physicalstrengthimprovement painrelieving mainsideeffectsmanifestedaslowfeverandlower etcwhichneededno 37)．The appetite special Zoledronicacidcan reliefthe ofmetastaticbonetumorswhichresistedtodiS0dium effectivelypain canpre