动脉粥样硬化性脑梗死急性期血清CD4%2fCD8和补体C3与疾病严重程度关系.pdfVIP

动脉粥样硬化性脑梗死急性期血清CD4/CD8 和补体C3 与疾病 严重程度的关系 刘 寰，聂志余，李艳成，管 强，何育生，陈玉辉 （同济大学医学院附属同济医院神经内科，上海 200065 ） 摘要：目的。探讨动脉粥样硬化性急性脑梗死患者血清CD4/CD8 及补体C3 的变化与病情轻重的关系。方法。采 用酶联免疫法及流式细胞仪测定共105 例急性脑梗死患者血清CD4/CD8 及补体C3 含量，根据入院时美国国立卫 生院卒中量表（NIHSS ）将患者分为重型脑梗死、中型脑梗死和轻型脑梗死三组，比较病情严重程度不同的动脉 粥样硬化性急性脑梗死患者血清中CD4/CD8 及补体C3 的水平。结果。CD4/CD8 与患者神经功能受损程度呈现 负相关，重型脑梗死组CD4/CD8 数值最低，轻型脑梗死组最高，三组比较其差异具有显著的统计学意义（P0.05 ）。 重型脑梗死组补体C3 含量高于中型脑梗死组和轻型脑梗死组，中型脑梗死组补体C3 含量高于轻型脑梗死组，三 组比较差异具有统计学意义（P0.05 ）。结论。CD4/CD8 与患者神经功能受损程度呈现负相关（P0.05 ），补体 C3 含量与患者神经功能受损程度呈现正相关（P0.05 ）。 关键词：动脉粥样硬化；脑梗死；CD4/CD8 ；补体C3 The Relationship between the Level of Serum CD4 / CD8 and C3 and Severity of Acute Atherosclerotic Cerebral Infarction LIU Huan, NIE Zhiyu, LI Yancheng, GUAN Qiang, HE Yusheng, CHEN Yuhui (Department of Neurology, Affiliated Tongji Hospital of Tongji University, Shanghai, 200065, China) Abstract: Objective .To study the relationship between the level of serum CD4 / CD8 and Complement 3(C3) and Severity of acute atherosclerotic cerebral infarction. Method. 105 patients with acute atherosclerotic cerebral infarction were enrolled in this study. Serum CD4 / CD8 and C3 levels were measured by Enzyme-Linked ImmunoSorbent Assay (ELISA) and Flow Cytometer respectively. The patients was divided into heavy (NIHSS 31-42), medium(16-30) and light(15) cerebral infarction groups based on the national institutes of health stroke scale (NIHSS). Results. CD4 /CD8 was negatively correlated with severity of neural function damage of the patients.(P 0.05), the level of CD4/CD8 in the heavy group is the lowest, and the highest the