上皮间质转化与恶性肿瘤的转移与侵袭_陈璐.pdfVIP

Chinese Journal of General Surgery Role of epithelial-mesenchymal transition in cancer invasion and metastasis CHEN Lu, CHEN Zihua (Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China) ABSTRACT Epithelial-mesenchymal transition (EMT) is closely related to cancer progression such as local invasion and distal metastases. h e down-regulation of epithelial marker (E-cadherins) and up-regulation of mesenchymal markers (vimentin and N-cadherin) in the cell surface is the main feature of EMT process. This paper addresses the recent progress in investigating the mechanism underlying cancer EMT. KEY WORDS Neoplasms/etiol; Epithelial-Mesenchymal Transition; Review CLC number: R730.2 Document code: A -