局部组织肾素-血管紧张素系统在皮肤损伤修复和再生中的作用.pdfVIP

中国病理生理杂志 ChineseJournalofPathophysiology 2011，27(1)：191—195 · 19l · [文章编号] 1000—4718(2011)01—0191—05 局部组织肾素 一血管紧张素系统在皮肤损伤修复 和再生中的作用 ：l： 刘宏伟 ， 程 飚 ， 付小兵 (暨南大学附属第一医院整形外科，再生医学教育部重点实验室，广东 广州510630；广州军区广州总医院整形外科 ，广东 广州 510010；解放军总医院第一附属医院全军创伤修复重点实验室，北京 100853) Updateon theroleofregionalrenin-—angiotensin system in cutaneouswound repairandregeneration LIU Hong—wei，CHENG Biao ，FU Xiao—bing。 (DepartmentofplasticSurgery，TheFirstAffiliatedHospitalof nUnivenity，KeyLaboratoryforRegenerative Medciine，MinistryofEducation，Guangzhou510630，China；DepartmentofPlastciSurgery，GuangzhouGeneral HospitalofPLA，Guangzhou510010，China；。InstituteforBasciResearch，TraumaCenterofPostgraduateMedcid College，GeneralHospitalofPL4，Beijing100853，hCina．E—mail：liuhongwei0521@hotmail．com) A【BSTRACT】 Accumulatingevidencehasindicatedthattheskincallserveasaperipheralneuroendocrineorgan， andisalsoatargetorganofhormonesand Thecutaneousneuroendocrinesystem playsacriticalrolein tissuerepairandregenerationthroughtheirspecialreceptorsinthepraacrineorautocrinemanner．Renin—angiotensinsys- tem(RAS)isoneoftheseveralimportanthomronalsystems，whichregulates~obalandlocalhomeostasis．Duringthelast decade，completelynewaspectshaveemceedinthefieldofRASresearch．ItisclerathatnagiotensinlI(AngII)，akey peptideofRAS，playsarolenotonlyinregulationofbloodpressureandbodyfluidsbutalsoincellproliferationnaddiffer- entiation．Ang1Ihasbeenshowedtobeinvolvedincutnaeousself—turnover，emb~onicdevelopmentas wellasrepair andremodeling．ThisreviewmainlypresentstheevidencethatskinisasourceandtargetorganofRAS，andRASplays rolesincutaneouswoundrepairandregeneration． [关键词] 肾素一血管紧张素系统；创伤愈合；激素 [KEYWORDS] Renin—angiotensinsystem；Woundhealing；Homrones