创伤后应激障碍病因和发病机制的研究进展.pdfVIP

医学与哲学( 临床决策论坛版) 2010 年 6 月第 31卷第 6 期总第407 期 创伤后应激障碍病因及发病机制的 究进展 ¹ ¹ ¹ º : (post- traumat ic st ress disorder , PTSD), , PTSD 1% ~ 14% , PTSD 3% ~ [ 1] 5 % , 。PTSD , , PTSD 。 : PTSD, , : R64 1 : A : 1002- 0772(2010) 06- 0049- 02 Th e Et iology an d Path ogen esis of Post- Traumat ic Stress Disorder L U Sha o2j ia , LI Ling2j iang GAO Wei2j ia , et a l . Menta l H eal th I nstitute, The Second Xiangya H ospita l , Cent al South Unive sity , Changsha 410011, China Ab stract : Post- traumatic stress disorder is a severe type of st ress- related disorder, which occur s after an individual fa2 cing with unusually intense mental stress. Reported in literatures, t he lifetime prevalence rate of PTSD was 1% to 14% . Studies of high2risk population found that the prevalence rate of PTSD was 3% to 5 % , female was about twice t o male. The etiology and pat hogenesis of post- traumatic stress disorder is very complex, which includes various aspects, in this review we try to summarize the development of etiology and pathogenesis of PTSD . K ey Word s: PTSD , et iology and pathogenesis, progress 1 热点, 究结果也存在较多的差异。大多数的 究发现 PTSD 尽管大量的遗传学 究已深入至许多精神疾病, 但是遗传 患者血促肾上腺皮质激素释放激素( CRH ) 较正常人明显地升 对PT SD 的影响至今仍知之甚少。最早的遗传学 究主要来源 高, PTSD 患者可能存在 CRH 的脱抑制, 而 CRH 能激活蓝斑去 于亲代和双胞胎的 究, 亲代 究发现 PTSD 大多发生于某些 甲肾上腺素能系统, 增加交感神经系统活性, 控制 CRH 水平可 家庭, 而双胞胎 究发现在经历同样的应激事件后单卵双生子