骨质疏松和骨性关节炎关系的研究进展_伦学刚.pdfVIP

# 87 6# 2007 12 20 12 Ch in a J O rthop T raum a, D ec 2007, V ol 20, N o 12 # # 伦学刚, 谈志龙, 白人骁 ( , 3002 11) = 骨质疏松( o steopo rosis, OP ) 与骨关节炎 ( osteoarthritis, OA ) 是临床常见病多发病, 骨质疏松症是以骨量 减少骨组织微细结构破坏导致骨 脆性和骨折危险性增加为特征的 一种系统性全身性骨 疾病而骨性关节炎是 以软骨改变为主要特征, 进而造成软骨下骨坏死, 囊性变, 骨密度增加和伴发骨赘形成的一种非特异性炎症骨质疏 松在骨关节炎发病过程中到底扮演什么角色, 是否为骨关节炎的病因之一, 国内外有大量文献对此进行了报道, 其观 点也不甚 一致, 目前存在 3种: ¹ OA 与 OP 正相关, O P 是 OA 的病因之一; º OA 与 OP 负相关, O P不是 OA 的病因; » OA 与 OP 不相关通过查阅文献, 笔者认为 OP 与 OA 不相关的可能性不大本文就两者之间的正负关系作 一综述, 以期能对以后的临床工作有 一定的指导作用 = 骨质疏松; 骨关节炎; 综述文献 A dvance in assoc ia tion of osteoporosis and osteoarth ritis L UN X ue-g ang, TAN Z h i-long, BA I R en-x iao. Th e Institute of O rthop aed ics of T ian inH o sp ita,l T ia ng in 300211, Ch ina AB STRACT Bo th osteopo rosis ( O P ) and osteoarthr itis ( OA ) are common in c linic w ith a h igh mo rb idity O steoporosis is a system atic bone d isease Its ch aracter istics include decrease in the bone m inera l content, increase in bone frag ility and increase in the risk o f fracture resu lting from dam age on m ic rostru cture o f bone H ow ever, the feature of osteoarthr itis is the ch ange in the ca rtilage, resulting in a non-sp ec ific inflamm ation w ith sub chondra l bone necro sis, cystis deg eneration, increase in bone m ine ra l den sity ( BM D ) and the osteophyte form ation The research on the ro le of the osteopo ros is plays in the occurrence o f osteo ar- th ritis and w he ther it is one o f the etio log ica l factors o f the osteoa rthr itis h as been repo rted by a large am ount o f dom estic and fore ign artic les T he v iew po ints o f tho se are no t u su a lly co inc ident, of w h ich there are th ree m a in op in ion s: ¹ OA and O P are in positive corr