急性重型颅脑创伤患者脑组织_血清蛋白质组分析.pdfVIP

160 ( Ch in J N urosurg D is R s) 2008; 7( 2) : 167 1- 2897( 2008) 07- 160- 03 * 张相彤 谢春成 尚振德 战华(, 15000 1) ; , , 13~ 39 8 : m / z3178m / z34 12m / z4201 m / z4692m / z8605m / z8676m / z9387m / z9607 , , , ; ; ; R 739. 41 A P roteom ics analysis of brain tissue and serum of patien ts w ith acute severe traum atic head injury ZHANG X iang tong, X IE Chuncheng, SHAN G Zhende, ZHAN H ua D ep ar tm ent of N eurosurg ery, The F ir stH osp ita of H arb in M edica University, H arbin 150001, China Abstract O bjective T o valuat significanc of scr ning d iff r ntial mark rs smi ultan ously both of brain and blood from pati nts w ith s v r traum atic brain injury and to stmi at th xt nt of traum atic brain injury dir ctly by using of th s rum biologicalm ark rs. M ethods Brain and b lood sampl s w r analyz d by using SELDI-TOF-MS. Som sp cial prot in points can b s arch d b wt n brain tissu and s rum. R esu lts Th sam 13~ 39 diff r ntial prot ins w r id ntifi d b tw n ach brain tissu and b lood sampl. Th sam 8 d iff r ntial prot ins w r d t ct d b tw n th whol brain tissu and blood sampl s, w ith th r lativ m ol cular w ight of m / z3178, m /z3412, m /z4201, m / z4692, m / z8605, m / z8676, m / z9387, m / z9607. Conc lusion D iff r ntial prot ins s arch d smi ultan ously can b utiliz d to stmi at th xt nt of traumatic brain injury to provid xp rmi ntal basis for valuation of brain injury by using diff r ntial prot ins. K ey w ords Prot om ics; Traumatic brain injury; Brain tissu ; S rum , , , 8 h [ 2] , , , , , J nk ins , , , [ 1] ,