阿苯达唑壳聚糖纳米胶体冻干粉针与研究.pdfVIP

阿苯达唑壳聚糖纳米胶体及冻干粉针的研究 王晓青，刘扬，张学农1* (苏州大学医学部药学院，江苏 苏州 215123) 摘 要 目的：研制阿苯达唑壳聚糖纳米粒(ABZ-CS-NPS)，并初步考察其冻干制 剂的制备。方法：采用乳化溶剂挥发法-TPP交联法制备阿苯达唑壳聚糖纳米粒； 均匀设计优化制备工艺；透射电镜、红外对纳米制剂进行考察；动态透析法探究 纳米粒的体外释放特性；冷冻干燥法制备纳米粒冻干制剂。结果：制得纳米粒形 态圆整，粒径分布均匀，载药量 (13.38±0.44)%，包封率 (79.57±0.96)%。冻干前 (157.8±2.82)nm (182.1±1.33)nm 0.1mol/LHCl 后的粒径分别为 和 。纳米粒在 、生 (0.9%NaCl) PBS(pH=5.3) Higuchi 理盐水 、 中的释放均遵循 方程。结论：阿苯达唑 纳米粒制备工艺简单，重复性好，冻干制剂外观和分散性良好。 关键词 ABZ-CS-NPS； 药剂学特性；体外释放； 冻干粉针 Studiesonpreparationof albendazole chitosan Nanoparticles Studiesonpreparationof albendazole chitosan Nanoparticles SSttuuddiieessoonnpprreeppaarraattiioonnooff aallbbeennddaazzoollee cchhiittoossaann NNaannooppaarrttiicclleess colloidand lyophilizedpowder colloidand lyophilizedpowder ccoollllooiiddaanndd llyyoopphhiilliizzeeddppoowwddeerr 1* WANG Xiao-qing, LIU Yang, ZHANG Xue-nong (Soochow University School of Pharmaceutical,Suzhou215123,Jiangsu,China) ABSTRACT ABSTRACT AABBSSTTRRAACCTT OBJECTIVE: To investigate the preparation of albendazole chitosan Nanoparticles and a preliminary study on the lyophilized powder. METHODS: Nanoparticles were prepared by Emulsion solvent evaporation -TPP Crosslinking method .The Uniform design was applied to optimize the technology of preparation. Electron microscopy and Fourier infrared chromatography were used to analysis their structural characteristics .Dynamic dialysis system was adopted to study the drug release from Nanoparticles in vitro. Freeze drying preliminary studied the lyophilized powder. RESULTS: The Nanoparticles were spherical in shape. The loading drug content and encapsulated efficiency of microspheres were 【作者简介】王晓青 (1986～)：女