TGFβ超家族在软骨发生发育和维持中的作用.pdfVIP

HEREDITAS (Beijing) 2008 8 , 30(8): 953―959 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2008.00953 TGF-β 杨冠, 杨晓 , 100071 : 转化生长因子β(Transforming growth factor β, TGF-β) 超家族包括 TGF-β和骨形态发生蛋白(Bone morphogenetic protein ，BMP) 两个亚家族。TGF-β超家族信号通路的配体、配体拮抗分子、受体、信号转导分 子均在软骨内成骨过程中发挥各自独特的作用, 参与调控软骨细胞的谱系分化、增殖、成熟、凋亡和矿化。BMP 信号能起始间充质细胞向软骨细胞分化并维持软骨细胞的特性, 在软骨发生过程中起主导作用; 在生长板发育 的过程中, BMP 信号促进软骨细胞的成熟, 促进成骨, 而TGF-β信号抑制软骨细胞的肥大分化, 维持生长板中适 量的软骨细胞; TGF-β信号和BMP 信号对于关节软骨的维持和修复都是不可或缺的。因此, TGF-β超家族的重要作 用贯穿骨骼发育过程的始终。 : 转化生长因子β; 骨形态发生蛋白; 软骨; 软骨内成骨; 骨骼发育 Roles of TGF-β superfamily in the genesis, development and maintenance of cartilage YANG Guan, YANG Xiao Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China Abstract: The transforming growth factor β (TGF-β) superfamily is composed of TGF-β subfamily and bone morphoge- netic protein (BMP) subfamily. The ligands, ligand antagonists, receptors and intracellular transductors that engage in the TGF-β superfamily signaling pathway play their unique roles during endochondral ossification via regulating the lineage differentiation, proliferation, maturation, apoptosis and mineralization of chondrocytes. BMP signaling dominates chondro- genesis through initiating the chondrocytic commitment of mesenchymal cells and maintaining the chondrocytic phenotype. During the development of growth plate, BMP signaling promotes the maturation of chondrocytes to facilitate ossification, whereas TGF-β signaling inhibits the hypertrophic differentiation to preserve adequate chondrocytes within the growth plate. Both TGF-β signaling and BMP signaling are indispensable for the maintenance and