乳腺癌中医证型与临床分期及分子标志物关系_易维真.pdfVIP

28 5 200910 JOURNAL OFANHUI TCM COLLEGE Vol.28 No.5 Oct.2009 23 易维真, 汪晓明, 张福忠,李华刚,马　卉 (, 　230031) :目的:探讨乳腺癌中医证型与临床分期及 激素受体(estrogen receptor, ER)、孕激素 受体(progesterone receptor, PR)和癌蛋白C-erbB-2关系。方法:选择经病理证实、有完整资料的 乳腺癌病例 95例,辨证分为肝郁痰凝、冲任失调、正虚毒炽3 种中医证型,采用免疫组织化学法对 各证型的临床分期及其分子标志物ER、PR、C-erbB-2 表达进行分析。结果:95 例中, 肝郁痰凝型 为71例,占74.74%,冲任失调型为9例,占9.47%,正虚毒炽型为15例,占15.79%。 Ⅰ期、Ⅱ期 乳腺癌中以肝郁痰凝型居多, 而Ⅲ期、Ⅳ期中正虚毒炽型所占比例高于肝郁痰凝型和冲任失调型。 肝郁痰凝型ER 阳性率与正虚毒炽型比较, 差异无显著性(P =0.074);肝郁痰凝型ER 阳性率与冲 任失调型比较, 差异有显著性(P =0.022)。各证型PR、C-erbB-2 阳性率比较, 差异无显著性。结 论:乳腺癌早期多为肝郁痰凝型, 后期以正虚毒炽型为主。肝郁痰凝型ER表达水平高于冲任失调 型,而PR、C-erbB-2 的表达与中医证型无明显相关性。 :乳腺癌;辨证分型; 激素受体;孕激素受体;C-erbB-2 :R737.9　:A 　:1000-2219(2009)05-0023-03 　　。 ,, , (es- , , trogen receptor, ER)、(progesterone [1-2] receptor, PR) C-erbB-2 。 ,, 。 , 1　 。 1.1　　①: ER、PR、C-erbB-2 , :(1963-), , , 。② 　　Abstract:Objective:To preli inarily investigate the characteristics of clinical sy pto s and syn- dro es of traditional Chinese edicine (TCM)in patients with hu an i unodeficiency virus (HIV )in- fection and acquired i unodeficiency syndro e (AIDS)in north Anhui province.Methods:The unifor clinical observation table and investigation sche es were established based on the ethod of TCM clinical epide iology.The frequency distribution of sy pto s, signs and TCM syndro e types was statistically described using Microsoft Office Excel database.Results:The HIV and AIDS patients were ostly infec- ted through blood route in north Anhui province.Their ost co on sy pto s were fatigue and short breath.In HIV phase, the syndro e type of deficiency of both qi and blood was ost co on;while in AIDS phase, the top 4 syndro es were the type of de