灵芝肽粉的抗辐射作用的研究.pdfVIP

灵芝肽粉的抗辐射作用研究 潘京一6杨 隽 丁愉 王 宁 董 铖 郑志清 肖萍 上海市疾病预防控制中心 中山西路1380号 200336 目的 观察灵芝肽粉对小鼠的辐射损伤的影响。方法 按照卫生部：保健食品检验与评价技术规范[s].2003-02-14 进行。结果 灵芝肽粉中、高剂量组能显著提高小鼠血清溶血素水平和抗体生成细胞数以及单核-巨噬细胞吞噬功能，使ConA 诱导的脾淋巴细胞增殖能力和NK细胞活性明显增强。灵芝肽粉中、高剂量组能显著提高受60Co-γ射线照射小鼠的外周血 白细胞数和小鼠血清溶血素水平，明显降低小鼠骨髓细胞微核率。结论 灵芝肽粉能增强小鼠的细胞免疫和体液免疫功能， 减轻血细胞辐射损伤，对辐射暴露具有一定的防护作用。 灵芝肽；辐射损伤；辐射防护；脂质过氧化 TheStudyontheAnti-radiatingDamageofGanodermapolypeptide inMice PANJing-yiYANG JunDING-yuWANGNingDONGchengZHENG Zhi-qingXIAOPing DivisionofToxicology,ShanghaiMunicipalCenterforDiseaseControlPrevention,Shanghai200336,China ObjectiveToinvestigatetheinfluencesofGanodermapolypeptideontheradiationdamage methodsaccordingtotheTechnicalStandardsforTestingAssessmentofHealthFood(2003edition)Chinese MinistryofSanitationResultsGanodermapolypeptideofmiddleandhighdosegroupcouldincreasetheamount ofhemolyticantibodyinserum.TheproliferationofConA-inducedmitogenicresponseforspleenlymphocytewas alsoincreased.GanodermapolypeptideofmiddleandhighdosegroupcouldenhancetheactivityofNKcelland theabilityofphagocytosisofhyalineleukocyteandmacrophagesignificantly.Comparedwiththeradiatingcontrol group,thenumberofWBCandtheserumhemolysinincreasedsignificantly.Themicronucleustestofbone marrowdecreasedsignificantly.ConclusionGanodermapolypeptidecanimprovecell-mediatedandhumoral immunefunction,decreasedradiationdamageofbloodcellsandprotectthemicefromradiationinjuries. Ganodermapolypeptide;radiationdamage;Radioprotection;Lipidperoxidation （经方差分j ÷相比 （经方 巨剂量组与． 【胞数成反b ：粉高剂量！ aol,1997,107:4 H,etal.Apopt~ ~):185-189.