血管生成素受体在口腔癌的表达及其意义.pdfVIP

% 618 % 2005 19 6 J Modern Somatol, November 2005, Vol 19, No. 6 武云霞 梁 萍 南欣荣 焦艳军 孙晓军 探讨血管生成素受体(Tie- 2) 在口腔癌的表达水平 其在口腔癌血管生成中的作用 采用免疫组化SABC 法,检测34 例口腔癌组织 16 例正常口腔粘膜组织中Tie- 2CD34 的表达 T ie- 2 CD34 在口腔癌微血管内皮细胞的表达明显高于正常口腔粘膜血管内皮细胞的表达( P 0. 05) 但随口腔癌病理 分级的升高, Tie- 2CD34 虽呈现递增趋势, 但组间比较无显著性差异( P 0.05) 在口腔癌中, 血管生成 增加, Tie- 2 可能参与口腔癌血管生成的调节 血管生成素受体 免疫组化 口腔癌 血管生成 Expression and significance of Tie- 2 receptor in oral squamous cell carcinoma W U Yunx ia, L IA N G Ping , NA N X inrong , et al . Dental Division, No. 1 T eaching Hosp ital, hanx i Medical University . Taiyuan 030001 Abstract Objective To investigate t e role of T ie- 2 receptor in oral squamous cell carcinoma. Methods Tie- 2 and CD34 protein expression in 34 oral squamous cell carcinoma ( OSCC) and 16 oral normal mucosa were detected by SABC immuno istoc emical tec nique. Results Tie- 2 and CD34 expressed at ig er level in OSCC t an in t e control oral mucosa( P 0. 05) ; but expression of Tie- 2 and CD34 w as not significantly positive correlated wit pat ological grade in OSCC( P 0.05) . Conclusion Angiogenesis is increased in OSCC, and Tie- 2 may be involved in t e OSCC angiogenesis regulation. Key ords Tie- 2 receptor Immuno istoc emistry Oral squamous cell carcinoma Angiogenesis 中图分类号: R739. 8 文献标识码: A ( Angiogenesis) : ! ( ) 11 ; ∀ ( ) 19 , #( ) 4 , 16 , 10 , , 6 , 9~ 52 1 34 [ 1] , / ! ∀ # ( angiopoietin, Ang ) / - 2 11 3 7 1 6 2 3 1 ( tyrosine kinase w it immunoglobulin - like and 8 3 5 epidermal growt factor omology domains, T