炎症因子和动脉粥样硬化.pdfVIP

156 20 10 31 2 Adv CardiovascD is,M arch 2010, Vol. 31, o. 2 李国华 李佳旻 ( 山东省千佛山医院心内科, 山东 济南 250014) Inflamm atory Factors in A th erosclerosis L I Guohua, L I J iam in (Cardiology Departmen,t Qianf oshanHosp ital in Shandong, Jinan 250014, China) : 100439 34 ( 2010) 020 15603 : R541. 4 : A DO I: 10. 3969 / .j issn. 100439 34. 20 10. 02. 002 : 在过去的几十年, 我们逐渐认识炎 在动脉粥样硬化及其并发 中的重要作用炎 和免疫应答在动脉粥样硬化形 成中的作用已经引起广泛的兴趣在动脉粥样硬化发展过程中, 从早期的损害到易损斑块的形成, 都有大量的炎 因子参与其中 现就炎 因子在动脉粥样硬化中作用的最近进展做一综述, 这些进展可能应用于早期发现预防和治疗动脉粥样硬化 : A bstrac t: O ve r the p ast decade, w e have com e to apprec iate a prom inen t ro le fo r inflamm ation in a therosc le rosis and its comp lica tion s. T he curren t notion th at inflamm ation and mi m une respon se contr ibu te to a therog enesis h as ga ined increased interest. It is now w ellestablished tha t from early lesion to vu lnerab le plaque fo rm a tion, num erou s in flamm a tory factors p articipa te in the disease process. T h is rev iew w ill prov ide an update on inflamm ato ry factors in a therosc lerosis. T his know ledg e can be used for mi proved ea rly detection, prevention and treatm ent of a therosc lerosis. K ey w ord s: a therosc le rosis inflamm ation inflamm atory fac to rs , , [ 1] , CRP, CRP [ 6, 8] , CRP CRP : ( 1) , , , [ 2, 3] [ 9] ( 2) CRP , , , , [ 10] ( 3) , , TB [ 4]