上皮性卵巢癌病因学研究进展.pdfVIP

中国癌症杂志 2014年第24卷第11期 《 》 CHINA ONCOLOGY 2014 Vol.24 No.11 861 上皮性卵巢癌病因学研究进展 纪晓宁 综述　丰有吉 审校 上海市第一人民医院，上海交通大学附属第一人民医院妇产科，上海 200080 　　［摘要］　上皮性卵巢癌是当今最致命的妇科肿瘤之一，也是妇产科临床诊断及治疗中的最大难点。究其 原因，除了早期缺乏明显的临床症状及有效的诊断方法外，还由于缺乏对上皮性卵巢癌发生、发展准确而全面 的认识，故相关研究旨在更好地掌握上皮性卵巢癌的发病机制，有望在今后的诊断及治疗中取得新的进展。 目前，上皮性卵巢癌公认的三大发病机制是：高促性腺激素理论、“二元论”和干细胞假说。本文对此作一 综述。 　　 ［关键词］　上皮性卵巢癌；起源；高促性腺激素；二元论；干细胞 　　DOI: 10.3969/j.issn.1007-3969.2014.11.011 　　中图分类号：R737.31　　文献标志码：A　　文章编号：1007-3639(2014)11-0861-04 Progress in study on etiology of ovarian epithelial cancer JI Xiao-ning, FENG You-ji (Department of Gynecology and Obstetrics, Shanghai First People’s Hospital, the Affiliated First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China) Correspondence to: FENG You-ji E-mail: fengyj4806@ 　　［Abstract ］ Epithelial ovarian cancer, which is one of the most lethal gynecological tumors, is also the biggest difficulty in the diagnosis and treatment of obstetrics and gynecology. In addition to the lack of early clinical symptoms and effective diagnostic methods, the reason includes the lack of accurate and comprehensive understanding of the development of epithelial ovarian cancer. Thus a lot of research aimed at better grasp of its pathogenesis, which is expected in the future progress of its diagnosis and treatment. Currently, three pathogenesis of epithelial ovarian cancer widely accepted are high gonadotropin theory, “dualism” hypothesis and stem cell hypothesis. This study discussed the theory above. 　［Key words ］ Epithelial ovarian cancer; Origin; Gonadotropin; Dualism; Stem cell 　 　 卵 巢 癌 是 妇 科 三 大 恶 性 肿 瘤 之 一 ， 病 死 1　来源 率 位 于 妇 科 肿 瘤 的 首 位 ［ 1 ］ 　　为了更好地探究上皮性卵巢癌的发病机制，