《Argonaute protein as a linker to command center of physiological processes》.pdfVIP

asalinkertocommandcenter Argonauteprotein of processes I(aifa Xie2 Weil，LingjuanWul，YanhuiChenl，YmaLinl，Yanmei Liul，Daoxin Wan91，Xiaoyao of Sciencesand Normal 1DepartmentBiological Biotechnology,MHlnan ofLife University,Zhangzhou363000，China；2School 100084，China University,Beijing to：Kaifa of Sciencesand Normal Xian Zhi CorrespondingWei，PhD．DepartmentBiological Qian Biotechnology,MinnanUniversity,36 Street， 363000，China．Email：kaifa—wei@163．com． Zhangzhou to Abstract：MicroRNAs(miRNAs)post—transcriptionallyregulategeneexpressionbybinding target mRNAswith or an that perfectimperfectcomplementarity,recruitingArgonaute(AGO)protein complex resultsin ortranslationalofthe mRNA．AGO as functionthe usually degradation repressiontarget proteins Slicer inmiRNAandsmall involvedinhuman enzyme interferingRNA(siRNA)pathways and physiological asantiviral anddisease the decade pathophysiologicalprocesses，suchresponses forma