《Association Between rs1344706 of ZNF804A and SchizophreniaA Metaanalysis》.pdfVIP

Genomics Proteomics Bioinformatics 12 (2014) 292–296 HO ST E D BY Genomics Proteomics Bioinformatics /locate/gpb LETTER Association Between rs1344706 of ZNF804A and Schizophrenia: A Meta-analysis Meiyan Zhu, Tongyang Liu, Jihong Zhang, Shuting Jia, Wenru Tang *, Ying Luo * Lab of Molecular Genetics of Aging Tumor, Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China Received 2 July 2014; revised 21 October 2014; accepted 24 October 2014 Available online 16 December 2014 Handled by Patrick Roth KEYWORDS Abstract Schizophrenia is one of the most serious mental diseases found in humans. Previous studies Meta-analysis; indicated that the single nucleotide polymorphism (SNP) rs1344706 in the gene ZNF804A encoding ZNF804A; zinc finger protein 804A was associated with schizophrenia in Caucasian population but not in Chi- Schizophrenia; nese Han population. However, current results are conflicting in Asian population. In the present Association; study, a meta-analysis was performed to revisit the association between rs1344706 and the risk of Caucasians; schizophrenia in Asian, Caucasian and other populations. Electronic search of PubMed database iden- Asians tified 25 case–control studies with available genotype frequencies of rs1344706 for the meta-analysis, involving a total of 15,788 cases and 22,654 controls. A pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. The current meta-analysis sho