《Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndromea Metaanalysis（英文版）》.pdfVIP

Chin Med Sci J Vol. 30, No. 1 March 2015 P. 44-50 CHINESE MEDICAL SCIENCES JOURNAL ORIGINAL ARTICLE Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis 1 1 2 Lei Qiu , Jing Liu , and Qi-ming Hei * 1Department of Health Management, 2Department of Labor and Social Security, School of Management, Hainan Medical University, Haikou 570100, China Key words: follicle stimulating hormone receptor; polycystic ovary syndrome; Meta-analysis; single-nucleotide polymorphism Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor (FSHR) gene and polycystic ovary syndrome (PCOS) susceptibility. Methods Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed, ISI web of knowledge, EBSCO, and China National Knowledge Infrastructure (CNKI) databases up to March 21, 2013. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses. Results A total of 11 studies were included in the Meta-analysis. The random-effect