《Association of glutathione peroxidase1 GPx1 rs1050450 Pro198Leu and Pro197Leu polymorphisms with cardiovascular risk：a metaanalysis of observational studies》.pdfVIP

Journal of Geriatric Cardiology (2014) 11: 141150 ©2014 JGC All rights reserved;   Research Article Open Access Association of glutathione peroxidase-1 (GPx-1) rs1050450 Pro198Leu and Pro197Leu polymorphisms with cardiovascular risk: a meta-analysis of ob- servational studies Jun-Xia ZHANG, Zhi-Mei WANG, Jun-Jie ZHANG, Lin-Lin ZHU, Xiao-Fei GAO, Shao-Liang CHEN Department of Cardiology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210006, China Abstract Objective To clarify the association between rs1050450 polymorphism in Glutathione peroxidase-1 (GPx-1) and the risk of cardi- ovascular diseases (CVD) by performing a meta-analysis of published studies. There is growing evidence from different study types for an association of the GPx-1 polymorphism and cardiovascular outcomes, but observational studies have so far shown inconsistent results. Me- thods Relevant publications were searched through PubMed, Embase database databases and the Cochrane Library. We used odds ratios