大脑中动脉供血区大面积脑梗死患者出现致死性脑水肿的早期预测因素.pdfVIP

82 Stro ke and Ner vou s Diseases, A pr 20 07 , V ol . 14, No . 2 崔 敏 张晓琴 陈文军 24 h ; , 72 , 26 , 46 ; log istic , 2 2 4 h N IHSS ( P = 0 . 017) ( P = 0. 00 1) 2 2 4 h NIH SS 24 R743 A 10 07047 8( 20 07) 020 08203 A study on the early predictors of fatal brain edema in large infarcts supplied by middle cerebral artery Cui M in, Zhang X iaoqin, Chen Wenj un . D ep ar tment of N eur ology , Zhong nan H osp ital of W uhan Univ er sity , W uhan 43 00 71 Abstract Objective T o inv est igate the ear ly pr edicto rs o atal Br ain edema o middle lar ge in arctio n cerebral arter y ( M CA) . Methods T his study w as a retr ospect ive casecontro l study o pat ient s w ho w ere w ith larg e M CA in ar ction and w er e admitt ed w ithin 2 4 hours a ter symptom onset . Case g roup w ere de ined as pa tients w ho died o atal br ain edema and contr ol gr oup w ere de ined as pat ient s w ho r ema ined living . W e ana ly zed the clinical, labo rator y and r adio gr aphic eatur es w ithin 24 ho ur s a ter symptom o nset . Results T here w ere 2 6 patients in the case g roup and 46 patients in the contro l g roup . M ultiv ariate log istic r egr ession o clini cal, labo rator y and radiog raphic eatures revealed N IHSS sco re o ver 24 w it hin 24 hours a ter symptom onset ( P = 0 . 017) and in arct area over M CA terr ito ry invo lv ement ( P = 0 . 0 01) as independent predictors o atal brain edema. Conclusions Pat ients w ith larg e M CA in arctio n are at high risk or develo ping at al br ain edema w hen their NI HSS sco re ex ceeded 2 4 w ithin 24 hours a ter sy mpt om o nset o r cer ebral in arctio n terr ito ry ex ceeded