橙皮苷衍生化改性及清除自由基研究.pdfVIP

, Journal ofAnhuiAgr.i Sci. 2009, 37( 30): 14544 14546, 14572 常俊香 傅真治 * 陈建秋, 杨轲, 胡志军 (, 210009) 橙皮苷和碳酸二甲酯为原料, 采用正交试验对Lew is酸在极性溶 中催化合成甲基橙皮苷的工艺进行了研究结果表明, 甲基橙 皮苷的最佳合成工艺为: 催化 用量为反应物总质量的 10%, 反应时间为 3 h,反应温度为 70 e ,碳酸二甲酯用量为理论用量的6倍, 甲 基橙皮苷的得率可达 23. 3%橙皮苷和甲基橙皮苷及其金属配合物对Fenton体系产生的# OH 有较好的清除作用 橙皮苷; 甲基橙皮苷; 配合物;羟基自由基 Q 946. 91 A 0517 6611(2009) 30 14544 03 Study on DerivativeChelation of Hesperidin and its Scavenging Effect on FreeRadicals CHEN Jian-qiu et a l ( Departm ent ofAnalytical Chem istry, Ch ina Pharm aceuticalUniversity, Nanjing, Jiangsu 210009) Abstract W ith hesperidin and dmi ethyl carbonate as the materials, the orthogonal testw as taken to study the synthesis process form ethyl hesperidin catalyzed by Lew is acid in polar solvent. The results show ed that the optmi al synthesis process form ethyl hesperidin was catalyst a m ount of10% of totalm ass of the reactant, reaction tmi e of 3 h, reaction temperature of70 e and dmi ethyl carbonate am ount of6 tmi es of the theoretical am ount, the yield rate of methyl hesperidin could reach 23. 3% under the condition. H esperidin, methyl hesperidinand and their m etal complex all had good scavenging effects on # OH produced by Fenton system. eywords H esperidin; Methyl hesperidin; Complex; # OH , (, ); ,Vp, , (, ); (, , ); (,# [ 1 2] , ) , 1. 2 1. 2. 1 , , , 50m l,, , , 3. 00 m l 10 [ 3] , ; m l, , ( [4] [ 1] , ; ) , , 287 nm [ 5] 1. 2. 2 ; , 50 ml, , , 1. 002. 003. 004. 00 ,; Fenton# OH