五没食子酰葡萄糖拮抗内毒素的体内研究.pdf

解放军药学学报 2010年 10月 20 日 第 26卷 第 5期 P ha rm J Ch in PLA, VOl. 26, N O. 5, Oc to ber 20, 2010 403 吕根法, 吴天顺, 郑宏治, 王晓红, 石宏伟, 王国治, 邓继兵 [ ] , - , -, -, , [ ] ; ; - [ ] R927. 1 [ ] A [] 1008-9926( 20 10) 05-0403-03 [ DO I] 10. 3969 / j. issn. 1008-9926. 2010. 05. 0 10 A Study of the Ant-i endotoxin of -1, 2, 3, 4, 6-penta-O-galloy-lD-glucopyranose in Vivo LV G n-fa, WU T ian-shun, ZHENG Hong-zhi, WANG X iao-hong, SH I Hong-w i, WANG Guo-zh i, DENG J-i b ing D partm nt of Burns and Plastic Surg ry, Hosp ital 534 of PLA, Luoyang 471003, Ch ina [ Abstract Objective To study th ff ct of anti- ndotox in of -1, 2, 3, 4, 6-p nta-O-galloyl-D-glucopyr- anos in v ivo . M ethod s Th ndotox in-n utralizing ff ct of -1, 2, 3, 4, 6-p nta-O-galloy-lD-glucopyranos w as assay d in ndotox m icN IH m ic w ith LAL, and th n utralization of ndotox in and suppr ssion of tumor n crosis factor-a r l as w r also obs rv d in lipopolysaccharid -chall ng d rats. W also t st dwh th r-1, 2, 3, 4, 6-p n- ta-O-galloyl-D-glucopyranos cou ld prot ct m ic from a l thal chall ng by lipopolysaccharid . R esu lts -1, 2, 3, 4, 6-p nta-O-galloyl-D-glucopyranos significantly d cr s d th p lasm a ndotox in l v l in ndotox in m ic and rats, w hich w as clos ly r lat d to th tumor n crosis factor-a l v .l An mi als pr trat dw ith -1, 2, 3, 4, 6-p nta-O-galloyl- D-glucopyranos show d a d lay d d ath tmi and w r prot ct d from lipopolysaccharid -induc d l thality. Con- clusion -1, 2, 3, 4, 6-p nta-O-galloy-lD-glucopyranos d v lops th ff ct of an t-i ndotox in in vivo, wh ich is asso- ciat d w ith th rol of n utralizing ndotox in. [Key w ord s ndotox in; -1, 2, 3, 4, 6-p nta-O-galloy-lD-glucopyranos ; tumor n crosis factor- ( lipopolysaccharid , LP