外文资料--DOESF1-ATPASESUBUNITγTURNINTHEWRONGDIRECTION.pdf

FEBS 26828 FEBS Letters 533 (2003) 1^8 Hypothesis Does F -ATPase subunit Q turn in the wrong direction? 1 Richard J. Berzborna ; ,Jurgen Schlitterb « aDepartment of Biochemistry of Plants, Ruhr-University Bochum, Biology, 44780 Bochum, Germany b Department of Biophysics, Ruhr-University Bochum, Biology, 44780 Bochum, Germany Received 12 July 2002; revised 12 November 2002; accepted 19 November 2002 First published online 28 November 2002 Edited by Vladimir Skulachev occupancies E (empty) TP (triphosphate binding) and DP Abstract Analyzing the direction of F -ATPase subunit QQ ro- 1 tation, its shape and non-random distribution of surface resi- (diphosphate binding) of the three L subunits is counter-clock- dues, a mechanism is proposed for how QQ induces the closing/ wise ,when viewed from above. Therefore ,if the interactions opening of the catalytic sites at LL/KK interfaces: by keeping with subunit Q determine the conformation and occupancy of contact with the mobile domain of subunits LL at the ‘jaw’ the three di¡erent subunits