葡萄糖代谢与胰岛素敏感性与分泌功能之间的内_省略_病学会_ADA_Banting.pdfVIP

2006 9 26 5 ∀ Intern J Endo rinol Metab, Sep 2006, Vol 26,No. 5 315 解读2006 年美国糖尿病学会(ADA) Banting 奖!演讲报告 谢云 ∀ ∀ # ∃ ∀ Bergman , , 3 : ( DI) 2 , DI; ; # ∃ ∀ ; ; The internalrelationship between the glycometabolism and insulin sensitivity / secretion function ∀ XIE Yun. Dep artment of Diabetic Neurop athy , The Metabolic DiseasesH osp ital of Tianj in Medical Uni ersity , Tianj in 300070, China # Abstract∃ ∀ Professor R. N. Bergman and his olleagues has designed the famous minimal model whi h ould des ribe the intera tion between glu ose and insulin. The model has been widely used to understand the in sulin sensitivity and ell fun tion for diabeti s and to play a a tive role in preventing ell fun tion failure for do tors to intervene and treat diabetes in lini . He explained the pathogenesis of diabetes from three aspe ts by using the minimal model: Disposition Index ( DI) was used to predi t type 2 diabetes and some andidate genes oding for DI were found. The disorder of apillary transendothelial transport an lead to insulin resistan e. Free fat a id made effe ts on regulating glu ose produ e in liver. # Key words∃ ∀ Glu ose metablism; Insulin sensitivity; Diabetes mellitus ( Intern J Endocrinol Metab, 2006, 26: 315316, 319) ∀ ∀ 66 ( ADA) , ( Minimal model Banting Ke k Method) Ri hard N. Bergman , , 3 ( ( Harmony and Dis ) , 7 ord in the Or hestration of Glu ose Metabolism)! ( Bergman ) , Bergman , : , dG = - S [ G( t) - G ] - X( t) G( t) , G( 0) = G G b b 3 dT : % ( disposition index, DI) 2 dx