Fas系统介导的细胞凋亡与桥本氏甲状腺炎关系的研究.pdf

·34· MedicalJournalofTrauma-and 伤，Ic医学毒志2004耳弟12基摹3期 Fas系统介导的细胞凋亡与桥本氏甲状腺炎关系的研究 关秀茹崔丽娟杜柏岩韩，丽辛晓敏 (哈尔滨医科大学第一·l盏床医学院实验诊断教研室，黑龙江哈尔滨150001) 摘要 目的：为了研究Fas／FasL介导的细胞凋亡在桥本氏甲状腺炎发病机制中的作用，评价其在治疗中的意义．方法： 强度显著高于正常对照组(尸O．01)，血浆sFas水平(2．05ng／ml 导的细胞凋亡与桥本氏甲状腺炎发病密切相关。 关键词桥本氏甲状腺炎；细胞凋亡；Fas抗原；Fas配体；可溶性Fas ontheRelationbetween InducedFas andHashimoto’S Study Apoptosisby System Thyroiditis The 150001 FirstAffiliatedofHarbinMedical Hospital University,Harbin a1． Bai-yan，et G￡从Ⅳ．硷”-，-l‘CU：Zi-iuatl,DU Abstract theroleof inducedFas／FasLinthe of Objective：Toinvestigation apoptosis by Hashimoto’S andtoevaluateits in courseand thyroiditis significancepathogenic blood from24casesofHTand35CaSeSof were forthe of anticoagulantsamples healthypersonsanalyzed Fas inT andforthe levelofsolubleFas flow and by cytometryassayer国cme antigenlymphocytesplasma separately was for linkedimmunosorbent immunohistochemical assay(ELISA)．Meanwhile，alltechniqueperformed Fas andFasL inthe from20additional 10cases thyroidadenoeytes antigen expression pathologic stainsinHTwere ofHTand FasandFasLimmunohistochemical healthypersonsrespectively．Resu