刷状聚乙二醇两亲性共聚物的合成及其对载药的影响研究进展.pdfVIP

化 工 进 展 2013 年第 32 卷第 12 期 CHEMICAL INDUSTRY AND ENGINEERING PROGRESS ·2793 · 特约评述 刷状聚乙二醇两亲性共聚物的合成及其对载药的影响研究进展 敬小波，申有青 （浙江大学化学工程与生物工程学系，浙江杭州 310027 ） 摘 要：刷状聚乙二醇（PEG ）两亲性共聚物具有独特的性能和良好的应用前景，日益受到人们的重视。本文综 述了刷状PEG 两亲性共聚物的两种合成策略，即大分子单体法和主链-侧链偶联法，它们主要通过离子聚合、自 由基聚合、开环聚合及各种耦合反应等实现。举例分析了这些方法的优缺点，并侧重于聚酯等生物可降解材料 形成的刷状PEG 共聚物。比较了直链PEG 和刷状PEG 共聚物胶束表面形态，简要分析了刷状PEG 结构对纳米 颗粒药物输送性能的影响，指出刷状PEG 结构能延长体内循环时间从而提高药物疗效，但有效的合成方法及其 胶束的体内外性能还需要更深入的探索。 关键词：聚乙二醇；刷状共聚物；合成；药物输送性能；纳米材料；表面 中图分类号：TQ 316.32 文献标志码：A 文章编号：1000 –6613 （2013 ）12 –2793 –07 DOI ：10.3969/j.issn.1000-6613.2013.12.001 Amphiphilic brush copolymers of poly(ethylene glycol) ：Synthesis and applications in drug delivery JING Xiaobo ，SHEN Youqing （Department of Chemical and Biological Engineering，Zhejiang University ，Hangzhou 310027，Zhejiang ，China ） Abstract：Brush copolymers with poly(ethylene glycol) (PEG) as side chains have received wide attentions due to their unique properties and potential applications. In this article ，the synthesis strategies ，including “grafting through” and “grafting onto” ，their specific advantages and limitations are reviewed ，with an emphasis on brush PEG copolymers based on biodegradable materials ，such as polyesters. In each strategy ，various polymerization techniques ，such as ionic polymerization ，radical polymerization ，ring opening polymerization and their compatible partner various coupling reactions ， are employed. Meanwhile ，the surface morphologies of the micelles built from linear PEG copolymers and brush PEG copolymers are illustrated in this article ，and the effects of the architecture of PEG brush on the formed nanopartic