奈达铂每周方案同期适形放疗治疗局部晚期鼻咽癌de临床研究.pdfVIP

现代肿瘤医学 2011年7月 第 19卷第 7期 MODERN0NC0L0GY。Ju1．2011，VOI．19 NO．7 ·1327· 奈达铂每周方案同期适形放疗治疗局部晚期鼻咽癌的临床研究 潘素明，陈志仁，丘全胜，郭明江，司徒慧晶 Nedaplatinweeklyprogram synchronizationconformalradiotherapyinthetreatmentofIo— callyadvancednasopharyngealcarcinoma PANSu—ming，CHENZhi—ren，QIUQuan—sheng，GuoMing—jiang，SITUHui—jing AffiliatedShaoguanHospitalofShantouUniversityMedicalCollege，Guangdong512025，China． 【Abstract1 Objective：ToinvestigatethetherapeuticeffectsandsideeffectsofweeklyNDPchemohterapyeom- binedwithradiotherapyintreatmentofpartlyadvancednasopharyngealcarcinoma(NPC)．Methods：Totalof81partly advancedNPC patientswererandomlydividedintoCRTgroupandRTrgoup．ThepatientsinRTgroupwereonlyad- ministratedbyeonformalradiationtherapy(3D—CRT)；ThepatientsinCRTgroupweretreatedbyweeklyNDPbe- sides3D—CRT．Theneralyandlong—term therapeuticeffects，aswellassideeffectsofpatientsin2 rgoupswere observed．Results：Thesurvivalrateofnasopharyngealmass：CRTrgoupwas12．2％ (5／41)，RTrgoupwas 20．0％ (8／40)；Necksurvivalrate：CRTrgoupwas17．1％ (7／41)，RTrgoupwas37．5％ (15／40)，CRT rgoupwassignificantlylowerthantheRTrgoup(P0．05)；CRTrgoupandtheRTrgoup1，3yearsurvivalrates were92．7％ (38／41)，75．6％ (31／41)and92．5％ (37／40)，70．0％ (28／40)respectively(P0．05)．Toxicity wasmainlyneutropeniaandora1mucositisofrgadem．Conclusion：Low—dosenedapllatinweeklyconcurrentwihtra— diatherapyinlocaladvancednasopharyngealcracinomacna increasethecervical lympheliminateratena dthetoxicity wasacceptable． K【eywords】nasopharyngealcracinoma；radiotherapy；DDP；weeklydosechemotherapy Modem Oneology2011，19(07)：1327—1329 摘【要】 目的：探讨周剂量奈达铂化疗同步适形放疗治疗局部晚期鼻咽癌的疗效及不良反应。方法：81例局 部晚期鼻咽癌患者，随机分为奈达铂同期适形放疗组 (CRT组)和单纯适形放疗组(RT组)。RT组患者仅行 适形放疗 ，CRT组患者在适形放疗的基础上加用奈达铂。观察两组患者的近期疗效、远期疗效和不 良反应。 结果：鼻咽部肿块残存率：CRT组为12．2％(5／41)，RT组为20．0％(8／40)；颈部肿块残存率：CRT组 为 1